IRIS
SCHENONE, SILVIA
 Distribuzione geografica
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Continente #
EU - Europa 21.702
Totale 21.702
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Nazione #
IT - Italia 21.702
Totale 21.702
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Città #
Genova 17.675
Rapallo 2.357
Genoa 1.638
Bordighera 32
Totale 21.702
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Nome #
Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells. 176
Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. 150
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 144
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 143
Fyn kinase in brain diseases and cancer: the search for inhibitors. 143
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. 140
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 135
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors 133
Analogs, formulations and derivatives of imatinib: A patent review 130
Synthetic SRC-kinase domain inhibitors and their structural requirements 125
Click Chemistry, A Potent Tool in Medicinal Sciences 124
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 123
ATP-competitive inhibitors of mTOR: an update. 122
The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel. 122
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. 121
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 121
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 120
Last findings on dual inhibitors of abl and SRC tyrosine-kinases. 120
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 120
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 118
N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity. 118
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 116
Using insights into Pim1 structure to design new anticancer drugs. 114
Src kinase inhibitors: an update on patented compounds 114
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 114
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions 113
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. 113
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors 113
Bcr-Abl tyrosine kinase inhibitors: A patent review 113
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme 113
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold 112
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 112
New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. 111
Allosteric inhibitors of Bcr-Abl: towards novel myristate-pocket binders. 111
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 111
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 111
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 111
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 110
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice 110
Insight into the allosteric inhibition of Abl kinase 109
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. 108
Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling. 108
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 108
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 108
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 107
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. 107
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 106
Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. 106
F508del-CFTR rescue: a matter of cell stress response. 106
4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents 106
Pyrazolo[3,4-d]pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells. 106
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 105
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 105
An update on dual Src/Abl inhibitors 104
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 104
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines. 104
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors 103
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 103
Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors 102
Antiangiogenic agents: an update on small molecule VEGFR inhibitors 101
(Hetero)aroyl esters of 2-(N-phthalimido)ethanol and analogues: parallel synthesis, anti-HIV-1 activity and cytotoxicity 101
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 101
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 101
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 101
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 100
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells 100
New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization 99
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D-QSAR a bassa dipendenza conformazionale” 99
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: A new route of epigenomic regulation 99
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 99
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 98
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 98
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 98
Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia 98
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 97
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 97
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms 97
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 97
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. 97
Synthesis and antiproliferative activity of basic thioanalogues of merbarone 97
New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34(+) cells. 96
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 96
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 96
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 96
New insights into small-molecule inhibitors of Bcr-Abl 94
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 94
Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays 94
Guanylated diamines, triamines, and polyamines: chemistry and biological properties. 94
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  93
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. 93
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation 93
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity. 93
A chemometric approach to predict A1 agonist effect of adenosine analogues 92
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 92
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 92
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 92
Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors. 91
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 91
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition 91
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 91
Totale 10.824
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Categoria #
all - tutte 59.094
article - articoli 46.802
book - libri 0
conference - conferenze 10.567
curatela - curatele 0
other - altro 0
patent - brevetti 1.172
selected - selezionate 0
volume - volumi 553
Totale 118.188
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019941 0 0 0 0 0 0 0 0 0 0 516 425
2019/20206.465 203 145 290 400 583 661 971 441 578 1.123 818 252
2020/20211.848 98 137 116 95 128 176 209 154 194 221 146 174
2021/20223.178 59 196 291 409 95 221 233 766 158 222 135 393
2022/20232.864 290 171 31 321 450 512 0 206 527 25 286 45
2023/20241.208 70 265 47 186 121 193 98 62 103 52 11 0
Totale 22.160