A series of pyrazolopyrimidine derivs. was prepd., and their cyclo-oxygenase inhibitory activity was screened. It was found that these compds. demonstrated antiproliferative and anti-inflammatory activity. Among the synthetic compd., I revealed interesting COX-2 activity and selectivity.
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity
SCHENONE, SILVIA;BRULLO, CHIARA;
2010-01-01
Abstract
A series of pyrazolopyrimidine derivs. was prepd., and their cyclo-oxygenase inhibitory activity was screened. It was found that these compds. demonstrated antiproliferative and anti-inflammatory activity. Among the synthetic compd., I revealed interesting COX-2 activity and selectivity.
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