Two series of 3-arylsulfonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones with potential anti-inflammatory and analgesic activity were prepd. and tested. Pharmacol. results revealed that all the title compds., endowed with an arylsulfonyl side chain, possess good antalgic activity and fair anti-inflammatory properties. The analgesic profile of the two series, evaluated by the acetic acid writhing test, showed that 3 of the compds. were active. Structure-activity relationships are briefly discussed.
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents
SCHENONE, SILVIA;BRUNO, OLGA;RANISE, ANGELO;BONDAVALLI, FRANCESCO;
2001-01-01
Abstract
Two series of 3-arylsulfonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones with potential anti-inflammatory and analgesic activity were prepd. and tested. Pharmacol. results revealed that all the title compds., endowed with an arylsulfonyl side chain, possess good antalgic activity and fair anti-inflammatory properties. The analgesic profile of the two series, evaluated by the acetic acid writhing test, showed that 3 of the compds. were active. Structure-activity relationships are briefly discussed.
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