| Nome |
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Synthesis of new pyrazolo[3,4-d]pyrimidines 6-alkyl substituted Bcr-Abl tyrosine kinase inhibitors, file e268c4c8-78c2-a6b7-e053-3a05fe0adea1
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117
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Formulated pyrazolo[3,4-d]pyrimidines active on GBM cell lines, file e268c4c9-e8b9-a6b7-e053-3a05fe0adea1
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116
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Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers., file e268c4c6-1079-a6b7-e053-3a05fe0adea1
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110
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The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme, file e268c4c8-4841-a6b7-e053-3a05fe0adea1
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109
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Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia, file e268c4c9-b37c-a6b7-e053-3a05fe0adea1
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106
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A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia, file e268c4cb-bb69-a6b7-e053-3a05fe0adea1
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106
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The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells, file e268c4cb-7132-a6b7-e053-3a05fe0adea1
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94
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Proton therapy and src family kinase inhibitor combined treatments on U87 human glioblastoma multiforme cell line, file e268c4cb-6133-a6b7-e053-3a05fe0adea1
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81
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Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors, file e268c4ca-0256-a6b7-e053-3a05fe0adea1
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80
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In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity, file e268c4cb-3035-a6b7-e053-3a05fe0adea1
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73
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Matrine in association with FD‑2 stimulates F508del‑cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809, file e268c4c8-48bf-a6b7-e053-3a05fe0adea1
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67
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A new strategy for glioblastoma treatment: In vitro and in vivo preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine dual Src/P-Glycoprotein inhibitor, file e268c4cb-3025-a6b7-e053-3a05fe0adea1
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66
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SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: A new route of epigenomic regulation, file e268c4c7-ec60-a6b7-e053-3a05fe0adea1
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59
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Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery, file e268c4c7-0be2-a6b7-e053-3a05fe0adea1
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55
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Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives, file e268c4ce-87bd-a6b7-e053-3a05fe0adea1
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50
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Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses, file e268c4cc-860d-a6b7-e053-3a05fe0adea1
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47
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Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents, file e268c4c5-f892-a6b7-e053-3a05fe0adea1
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43
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Synthesis, antimicrobial activity and molecular modelling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles, file e268c4c5-fb23-a6b7-e053-3a05fe0adea1
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33
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Synthesis and biological evaluation of neutrophilic inflammation inhibitors, file e268c4c6-10e8-a6b7-e053-3a05fe0adea1
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33
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Exploring SAR of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn tyrosine kinase inhibitors, file e268c4c9-bafa-a6b7-e053-3a05fe0adea1
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32
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Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions, file e268c4c5-f6c4-a6b7-e053-3a05fe0adea1
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25
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Identification of a new family of pyrimidine and pyridine derivatives as disruptors of the viral RNA-dependent RNA polymerase, file e268c4c9-f42f-a6b7-e053-3a05fe0adea1
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21
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Synthesis of a new generation of pyrazolo[3,4-d]pyrimidine as SGK-1 inhibitors., file e268c4c8-77fe-a6b7-e053-3a05fe0adea1
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20
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Pyrazolo[3,4-d]pyrimidines as tyrosine kinase inhibitors: synthesis and biological evaluation, file e268c4c9-bafd-a6b7-e053-3a05fe0adea1
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16
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New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation, file e268c4c6-14dd-a6b7-e053-3a05fe0adea1
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15
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Synthesis of a small library of potential SGK1 inihibitors, file e268c4ca-13f1-a6b7-e053-3a05fe0adea1
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15
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3-Cyano-4,6-diphenyl-pyridine amino acid derivatives active as influenza A polymerase inhibitors, file e268c4c9-f431-a6b7-e053-3a05fe0adea1
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13
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Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma, file e268c4ce-5c4c-a6b7-e053-3a05fe0adea1
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13
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Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives., file e268c4c5-eab5-a6b7-e053-3a05fe0adea1
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12
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SGK1 as a new target for anticancer agents: a hit-to-lead study, file e268c4c8-7eb4-a6b7-e053-3a05fe0adea1
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11
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Pyrazolo[3,4-d]pyrimidine active on neuroblastoma cells, file e268c4ca-13dd-a6b7-e053-3a05fe0adea1
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11
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Antiangiogenic agents: an update on small molecule VEGFR inhibitors, file e268c4c5-f70f-a6b7-e053-3a05fe0adea1
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10
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Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones , file e268c4c6-11eb-a6b7-e053-3a05fe0adea1
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10
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Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells, file e268c4c6-13d5-a6b7-e053-3a05fe0adea1
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10
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Formulation Of Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors For The Treatment Of Glioblastoma Multiforme, file e268c4ca-984a-a6b7-e053-3a05fe0adea1
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9
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2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity, file e268c4c5-fa05-a6b7-e053-3a05fe0adea1
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8
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Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme., file e268c4c6-17e8-a6b7-e053-3a05fe0adea1
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8
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Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model., file e268c4c8-7802-a6b7-e053-3a05fe0adea1
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8
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Click Chemistry, A Potent Tool in Medicinal Sciences, file e268c4cb-4b4f-a6b7-e053-3a05fe0adea1
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8
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Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors, file e268c4cd-7e27-a6b7-e053-3a05fe0adea1
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8
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Synthesis of new piperazine-pyridazinone derivatives and their binding affinity toward alpha1-, alpha2-adrenergic and 5-HT1A serotoninergic receptors., file e268c4c5-f173-a6b7-e053-3a05fe0adea1
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7
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New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities, file e268c4c5-f8fe-a6b7-e053-3a05fe0adea1
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7
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Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays, file e268c4c8-79a7-a6b7-e053-3a05fe0adea1
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7
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AuNP Pyrazolo[3,4- d]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma, file e268c4cd-584a-a6b7-e053-3a05fe0adea1
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7
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Journey on naphthoquinone and anthraquinone derivatives: New insights in alzheimer’s disease, file e268c4cd-879b-a6b7-e053-3a05fe0adea1
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7
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Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling., file e268c4c5-f066-a6b7-e053-3a05fe0adea1
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6
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Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis, file e268c4c5-faff-a6b7-e053-3a05fe0adea1
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6
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Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists., file e268c4c8-792a-a6b7-e053-3a05fe0adea1
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6
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Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device, file e268c4cb-eaa1-a6b7-e053-3a05fe0adea1
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6
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Pyrazolo[3,4-d]pyrimidine tyrosine kinase inhibitors induce oxidative stress in patient-derived glioblastoma cells, file e268c4ce-7fd6-a6b7-e053-3a05fe0adea1
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6
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Anti-Survival Effect of SI306 and Its Derivatives on Human Glioblastoma Cells, file 25241f4c-b736-4ac7-8224-11cf2d18be0d
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5
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Synthetic SRC-kinase domain inhibitors and their structural requirements, file e268c4c5-f176-a6b7-e053-3a05fe0adea1
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5
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2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis, file e268c4c5-fa2a-a6b7-e053-3a05fe0adea1
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5
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Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors, file e268c4c8-4ad0-a6b7-e053-3a05fe0adea1
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5
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6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma, file e268c4c8-7d81-a6b7-e053-3a05fe0adea1
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5
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Synthesis of heterocyclic compounds to be tested as potentiators or correctors of mutant CFTR in cystic fibrosis, file e268c4c8-7d84-a6b7-e053-3a05fe0adea1
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5
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Src inhibitors pyrazolo[3,4-d]pyrimidines, si306 and pro-si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo, file e268c4cd-6c0e-a6b7-e053-3a05fe0adea1
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5
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New therapeutic strategy for overcoming multidrug resistance in cancer cells with pyrazolo[3,4‐d]pyrimidine tyrosine kinase inhibitors, file e268c4ce-7fd8-a6b7-e053-3a05fe0adea1
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5
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Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme, file 7f40cdc2-3d77-4a2b-8fd5-9ded7b0f421c
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4
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Pyrazolo[3,4-d]pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells., file e268c4c5-f171-a6b7-e053-3a05fe0adea1
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4
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SRC inhibitors and angiogenesis, file e268c4c5-f175-a6b7-e053-3a05fe0adea1
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4
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New pyrazolo[3,4-b]pyridones as selective A1 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies, file e268c4c5-f84f-a6b7-e053-3a05fe0adea1
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4
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Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study, file e268c4c5-faae-a6b7-e053-3a05fe0adea1
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4
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Affinity prediction on A1 adenosine receptor agonists: the chemometric approach, file e268c4c5-fc2b-a6b7-e053-3a05fe0adea1
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4
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Insight into Fyn and SGK1 kinases as new targets in medicinal chemistry: design and synthesis of pyrazolo[3,4-d]pyrimidine libraries, file e268c4c8-792c-a6b7-e053-3a05fe0adea1
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4
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An Update on JAK Inhibitors, file e268c4cb-299c-a6b7-e053-3a05fe0adea1
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4
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Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents, file e268c4ce-7687-a6b7-e053-3a05fe0adea1
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4
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 4-AMINO-PYRAZOLO[3,4-d]PYRIMIDINES
AS POTENTIAL SRC KINASE INHIBITORS, file 00ed6913-fabc-4c49-a110-e3794c8785be
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3
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N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds., file e268c4c5-f143-a6b7-e053-3a05fe0adea1
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3
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Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line, file e268c4c6-0060-a6b7-e053-3a05fe0adea1
|
3
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SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition, file e268c4c7-b763-a6b7-e053-3a05fe0adea1
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3
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Pyrrolo[2,3-d]pyrimidines as kinase inhibitors, file e268c4c8-4808-a6b7-e053-3a05fe0adea1
|
3
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Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment, file 4b9afe48-77a9-466b-90f9-8ed6500aae3b
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2
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Small Molecule Tyrosine Kinase Inhibitors (TKIs) for
Glioblastoma Treatment, file 680fb5d5-fe00-4f94-919b-52d19e17f680
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2
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Construction and validation of a RET TK catalytic domain by homology, file e268c4c5-f178-a6b7-e053-3a05fe0adea1
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2
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Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors, file e268c4c5-f194-a6b7-e053-3a05fe0adea1
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2
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Synthesis and antiproliferative activity of basic thioanalogues of merbarone, file e268c4c6-01d3-a6b7-e053-3a05fe0adea1
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2
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Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms, file e268c4c6-122b-a6b7-e053-3a05fe0adea1
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2
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Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors, file e268c4c6-124d-a6b7-e053-3a05fe0adea1
|
2
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Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice, file e268c4c6-14e2-a6b7-e053-3a05fe0adea1
|
2
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Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction, file e268c4c9-296c-a6b7-e053-3a05fe0adea1
|
2
|
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Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma, file e268c4c9-420d-a6b7-e053-3a05fe0adea1
|
2
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Analogs, formulations and derivatives of imatinib: A patent review, file e268c4cb-5496-a6b7-e053-3a05fe0adea1
|
2
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Synthesis of hybrid small molecules as potential PA-PB1 heterodimer disruptors of Influenza virus Polymerase, file e268c4ce-221f-a6b7-e053-3a05fe0adea1
|
2
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Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors, file e268c4ce-40df-a6b7-e053-3a05fe0adea1
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2
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Structure-Based Virtual Screening (SBVS) in flexible systems: the case of SIRT-2, file f20973c8-d535-4c51-b5ca-8b3e1215f98d
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2
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Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy, file 69153fb5-2f44-482a-943b-9ddcd117b35b
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1
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Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors, file a5dc6810-ac48-47db-b612-615c6afb2983
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1
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Last findings on dual inhibitors of abl and SRC tyrosine-kinases., file e268c4c5-f065-a6b7-e053-3a05fe0adea1
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1
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A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors., file e268c4c5-f172-a6b7-e053-3a05fe0adea1
|
1
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Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents., file e268c4c5-f174-a6b7-e053-3a05fe0adea1
|
1
|
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Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells., file e268c4c5-f177-a6b7-e053-3a05fe0adea1
|
1
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Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation, file e268c4c5-f237-a6b7-e053-3a05fe0adea1
|
1
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Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors, file e268c4c5-f73f-a6b7-e053-3a05fe0adea1
|
1
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|
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells, file e268c4c6-0e5e-a6b7-e053-3a05fe0adea1
|
1
|
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New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells., file e268c4c6-122d-a6b7-e053-3a05fe0adea1
|
1
|
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1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors, file e268c4c6-13da-a6b7-e053-3a05fe0adea1
|
1
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Src inhibition potentiates antitumoral effect of paclitaxel by blocking tumor-induced angiogenesis, file e268c4c6-186a-a6b7-e053-3a05fe0adea1
|
1
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Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma., file e268c4c6-2d30-a6b7-e053-3a05fe0adea1
|
1
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Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors, file e268c4c6-93b6-a6b7-e053-3a05fe0adea1
|
1
|
| Totale |
1.926 |