IRIS
BONDAVALLI, FRANCESCO
 Distribuzione geografica
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Continente #
EU - Europa 12.172
Totale 12.172
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Nazione #
IT - Italia 12.172
Totale 12.172
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Città #
Genova 9.467
Rapallo 1.383
Genoa 1.091
Vado Ligure 217
Bordighera 14
Totale 12.172
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Nome #
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 155
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 145
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 125
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 124
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 122
Synthesis and reactivity of (1S,4S,5S) -5-bromo-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine. X Ray-molecular structure and absolute configuration of E and Z isomers of (1S,4S)-5,5-dibromo-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine, the first case of separated nitrimine isomers. 118
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 118
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 117
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions 115
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 115
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 114
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 113
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 113
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 113
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice 112
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 111
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 111
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 110
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 110
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 109
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 108
Synthesis and pharmacological activity of derivatives of exo- trimethylenenorbornane. I 107
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 107
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 102
Antiangiogenic agents: an update on small molecule VEGFR inhibitors 102
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 102
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 102
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 102
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 101
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 101
The reaction of Terpenoid Nitrimines with secondary amines; a new route to Terpenoid Enamines 101
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 101
Synthesis and antiproliferative activity of basic thioanalogues of merbarone 101
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 100
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms 100
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 99
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 99
A chemometric approach to predict A1 agonist effect of adenosine analogues 97
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 97
Carbonyl transposition and regio- and stereo-specific syntheses of new alcohols, amino-alcohols and ketones in the monoterpenoid 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane 97
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  95
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 94
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 94
Derivatives of 4,5,6,7-Tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-Indazole with hypoglycemic and hypotensive activities 93
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 93
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 92
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives. 91
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 91
2- And 5-substituted 5-amino-2,6,6-trimethyltetrahydropyrans 91
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 90
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 90
N-acyl-4,7,7-trimethyl-N-phenyl-3-(1-piperidinyl or dimethylamino)bicyclo[2.2.1]hept-2-ene-2-carbothioamides with platelet antiaggregating and other activities. 89
O-[2-Hydroxy-3-(dialkylamino)propyl]ethers of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime (camphor oxime) with analgesic and antiarrhythmic activities 89
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 86
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 86
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 86
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 86
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 86
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 86
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 85
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 85
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 84
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 84
Reactions of the potassium salt of 1,7,7-trimethyl-N-nitrobicyclo[2.2.1] heptan-2-imine with bromine and nitrous acid: Synthesis of 3-exo-bromo-1,7,7-trimethyl-N-nitrobicyclo[2.2.1]heptan-2-imine, 3-endo-bromo-1,7,7-trimethyl-N-nitrobicyclo[2.2.1]heptan-2-imine, 1,7,7-trimethyl-N-nitro-3-nitrosobicyclo[2.2.1]hept-2-en-2-amine and their reactions with nitrogen nucleophiles. 84
N-Substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides with antiinflammatory and analgesic activities 83
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 83
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 83
N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties. 83
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 83
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 82
New selective PDE4D inhibitors able to discriminate between long, short and supershort isoforms 81
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 81
N-Monosubstituted Urethanes of 6-cis-Dialkylamino-1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ols with hypotensive and other activities 81
N-Monosubstituted Urethanes and Esters of 6-cis-Dimethylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol with hypotensive and other activities 81
5-[[ω-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities 81
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 80
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 79
O-[ω-(dialkylamino)alkyl]oximes of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one with hypotensive, antiinflammatory, analgesic, local anesthetic and other activities 79
ω-Dialkylaminoalkyl ethers of 6-(benzyl or phenyl)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol with platelet antiaggregating and local anesthetic activities 78
Synthesis and Reactivity of (1S,4R)-5-Hydroxyimino-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine. 78
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 78
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 78
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 77
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 77
5-Substituted 2,3-dihydro-6-mercapto-1,3-diphenyl-2-thioxo-4(3H)-pyrimidinones and their 6-(acylthio) derivatives with platelet antiaggregating, antiinflammatory, antiarrhythmic, antihyperlipidemic and other activities. 77
Derivatives of 1,3,3-Trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity 77
Syntheses of New Amine Derivatives and Carbonyl Transposition in the 1,7,7-Trimethylbicyclo[2.2.1]Heptane 77
3-Hydroxyiminocamphornitrimine and Camphorquinone Dinitrimine, Compounds previously described as N-Nitro-3-nitrosocamphorenamine.and N-Nitro-N,3-Dinitrosocamphorenamine. Crystal Structure of Camphorquinone Dinitrimine. 77
New pyrazolo[3,4-b]pyridones as selective A1 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies 76
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 76
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 76
Derivatives of 4,5,6,7-tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-indazole with hypotensive and hypoglycemic activities. (II) 76
Syntheses of 1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-5-ene(2,3-didehydro-1, 8-cineole), 6,6-dimethyl-2-methylene-7-oxabicyclo[3.2.1]octane (Isopinol), 2,6,6-trimethyl-7-oxabicyclo[1.2.1]oct-2-ene (Pinol) and 1-(3-isopropylidenecyclopentyl)ethanone (Pinolone) from hydroxy- and bromo-derivatives of Cineole 75
Esters of 6-Cis-dialkyilamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ols with hypotensive and other activities 74
N-Phenyl 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octan-6-cis-Amine Derivatives with hypotensive activity 74
Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonane with antiarrhythmic, local anesthetic and hypotensive activities. II 74
3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities. 74
Bamford-Stevens reaction of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one p-tolylsulphonylhydrazone 72
N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities. 72
Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity. 72
Totale 9.331
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Categoria #
all - tutte 34.192
article - articoli 28.011
book - libri 0
conference - conferenze 5.214
curatela - curatele 0
other - altro 0
patent - brevetti 967
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Totale 68.384
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.981 0 0 170 155 277 337 475 133 233 623 448 130
2020/2021567 24 47 35 28 26 72 29 36 79 41 67 83
2021/20221.646 31 154 95 250 54 110 158 348 40 128 79 199
2022/20231.667 181 101 16 170 320 307 0 113 275 11 152 21
2023/2024808 39 134 12 100 76 159 30 27 57 7 43 124
2024/2025230 33 185 12 0 0 0 0 0 0 0 0 0
Totale 12.263