IRIS
BONDAVALLI, FRANCESCO
 Distribuzione geografica
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Continente #
EU - Europa 11.775
Totale 11.775
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Nazione #
IT - Italia 11.775
Totale 11.775
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Città #
Genova 9.467
Rapallo 1.383
Genoa 911
Bordighera 14
Totale 11.775
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Nome #
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 150
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 144
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 120
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 120
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 118
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 116
Synthesis and reactivity of (1S,4S,5S) -5-bromo-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine. X Ray-molecular structure and absolute configuration of E and Z isomers of (1S,4S)-5,5-dibromo-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine, the first case of separated nitrimine isomers. 115
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 114
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions 113
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 112
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 111
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 111
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 110
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 110
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice 110
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 108
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 108
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 107
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 106
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 106
Synthesis and pharmacological activity of derivatives of exo- trimethylenenorbornane. I 105
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 105
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 104
Antiangiogenic agents: an update on small molecule VEGFR inhibitors 101
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 101
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 100
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 99
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 98
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 98
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 98
The reaction of Terpenoid Nitrimines with secondary amines; a new route to Terpenoid Enamines 98
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 98
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 98
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 97
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms 97
Synthesis and antiproliferative activity of basic thioanalogues of merbarone 97
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 96
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 96
Carbonyl transposition and regio- and stereo-specific syntheses of new alcohols, amino-alcohols and ketones in the monoterpenoid 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane 94
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  93
A chemometric approach to predict A1 agonist effect of adenosine analogues 92
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 92
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 92
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 91
Derivatives of 4,5,6,7-Tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-Indazole with hypoglycemic and hypotensive activities 91
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 90
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives. 88
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 88
O-[2-Hydroxy-3-(dialkylamino)propyl]ethers of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime (camphor oxime) with analgesic and antiarrhythmic activities 88
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 87
N-acyl-4,7,7-trimethyl-N-phenyl-3-(1-piperidinyl or dimethylamino)bicyclo[2.2.1]hept-2-ene-2-carbothioamides with platelet antiaggregating and other activities. 87
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 86
2- And 5-substituted 5-amino-2,6,6-trimethyltetrahydropyrans 86
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 85
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 85
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 85
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 84
Reactions of the potassium salt of 1,7,7-trimethyl-N-nitrobicyclo[2.2.1] heptan-2-imine with bromine and nitrous acid: Synthesis of 3-exo-bromo-1,7,7-trimethyl-N-nitrobicyclo[2.2.1]heptan-2-imine, 3-endo-bromo-1,7,7-trimethyl-N-nitrobicyclo[2.2.1]heptan-2-imine, 1,7,7-trimethyl-N-nitro-3-nitrosobicyclo[2.2.1]hept-2-en-2-amine and their reactions with nitrogen nucleophiles. 83
N-Substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides with antiinflammatory and analgesic activities 82
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 82
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 82
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 81
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 81
N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties. 81
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 81
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 81
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 81
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 80
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 80
N-Monosubstituted Urethanes and Esters of 6-cis-Dimethylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol with hypotensive and other activities 80
New selective PDE4D inhibitors able to discriminate between long, short and supershort isoforms 79
N-Monosubstituted Urethanes of 6-cis-Dialkylamino-1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ols with hypotensive and other activities 79
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 79
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 78
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 78
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 78
O-[ω-(dialkylamino)alkyl]oximes of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one with hypotensive, antiinflammatory, analgesic, local anesthetic and other activities 78
5-[[ω-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities 78
ω-Dialkylaminoalkyl ethers of 6-(benzyl or phenyl)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol with platelet antiaggregating and local anesthetic activities 77
Derivatives of 1,3,3-Trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity 76
Synthesis and Reactivity of (1S,4R)-5-Hydroxyimino-1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine. 76
New pyrazolo[3,4-b]pyridones as selective A1 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies 75
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 75
5-Substituted 2,3-dihydro-6-mercapto-1,3-diphenyl-2-thioxo-4(3H)-pyrimidinones and their 6-(acylthio) derivatives with platelet antiaggregating, antiinflammatory, antiarrhythmic, antihyperlipidemic and other activities. 74
Syntheses of New Amine Derivatives and Carbonyl Transposition in the 1,7,7-Trimethylbicyclo[2.2.1]Heptane 74
3-Hydroxyiminocamphornitrimine and Camphorquinone Dinitrimine, Compounds previously described as N-Nitro-3-nitrosocamphorenamine.and N-Nitro-N,3-Dinitrosocamphorenamine. Crystal Structure of Camphorquinone Dinitrimine. 74
Derivatives of 4,5,6,7-tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-indazole with hypotensive and hypoglycemic activities. (II) 74
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 73
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 72
Esters of 6-Cis-dialkyilamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ols with hypotensive and other activities 72
N-Phenyl 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octan-6-cis-Amine Derivatives with hypotensive activity 72
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 72
3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities. 72
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 72
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 71
Syntheses of 1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-5-ene(2,3-didehydro-1, 8-cineole), 6,6-dimethyl-2-methylene-7-oxabicyclo[3.2.1]octane (Isopinol), 2,6,6-trimethyl-7-oxabicyclo[1.2.1]oct-2-ene (Pinol) and 1-(3-isopropylidenecyclopentyl)ethanone (Pinolone) from hydroxy- and bromo-derivatives of Cineole 71
omega-Dialkylaminoalkyl esters of N-phenyl aminethiocarboximidic acids with local anesthetic and other activities. 71
New policyclic pyrimidine derivatives with antiplatelet in vitro activity: synthesis and pharmacological screening 71
N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities. 70
Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity. 70
Totale 9.065
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Categoria #
all - tutte 29.665
article - articoli 24.435
book - libri 0
conference - conferenze 4.407
curatela - curatele 0
other - altro 0
patent - brevetti 823
selected - selezionate 0
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Totale 59.330
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019305 0 0 0 0 0 0 0 0 0 0 172 133
2019/20203.096 66 49 170 155 277 337 475 133 233 623 448 130
2020/2021567 24 47 35 28 26 72 29 36 79 41 67 83
2021/20221.646 31 154 95 250 54 110 158 348 40 128 79 199
2022/20231.667 181 101 16 170 320 307 0 113 275 11 152 21
2023/2024641 39 134 12 100 76 159 30 27 57 7 0 0
Totale 11.866