Title ethers I [R = Ph, CH2Ph, n = 2, NR12 = NEt2, N(CHMe2)2, 1-pyrrolidinyl, piperidino, morpholino; R = Ph, CH2Ph, n = 3, NR12 = NEt3; R = CH2Ph n = 2, NR12 = NMe2; R = CH2Ph, n = 2, NR12 = piperidino] were prepd. by treating alcs. II with Cl(CH2)n NR12 and NaH in toluene. II were prepd. by the Grignard reaction of ketone III with PhMgBr of PhCH2MgCl. Some I, in particular those derived from I (R = Ph), showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid, as well as an appreciable local anesthetic activity and weak sedative effect in mice.
ω-Dialkylaminoalkyl ethers of 6-(benzyl or phenyl)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol with platelet antiaggregating and local anesthetic activities
SCHENONE, SILVIA;BRUNO, OLGA;RANISE, ANGELO;BONDAVALLI, FRANCESCO;
1990-01-01
Abstract
Title ethers I [R = Ph, CH2Ph, n = 2, NR12 = NEt2, N(CHMe2)2, 1-pyrrolidinyl, piperidino, morpholino; R = Ph, CH2Ph, n = 3, NR12 = NEt3; R = CH2Ph n = 2, NR12 = NMe2; R = CH2Ph, n = 2, NR12 = piperidino] were prepd. by treating alcs. II with Cl(CH2)n NR12 and NaH in toluene. II were prepd. by the Grignard reaction of ketone III with PhMgBr of PhCH2MgCl. Some I, in particular those derived from I (R = Ph), showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid, as well as an appreciable local anesthetic activity and weak sedative effect in mice.
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