CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishTitle ethers I [R = Ph, CH2Ph, n = 2, NR12 = NEt2, N(CHMe2)2, 1-pyrrolidinyl, piperidino, morpholino; R = Ph, CH2Ph, n = 3, NR12 = NEt3; R = CH2Ph n = 2, NR12 = NMe2; R = CH2Ph, n = 2, NR12 = piperidino] were prepd. by treating alcs. II with Cl(CH2)n NR12 and NaH in toluene. II were prepd. by the Grignard reaction of ketone III with PhMgBr of PhCH2MgCl. Some I, in particular those derived from I (R = Ph), showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid, as well as an appreciable local anesthetic activity and weak sedative effect in mice.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | ω-Dialkylaminoalkyl ethers of 6-(benzyl or phenyl)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol with platelet antiaggregating and local anesthetic activities |
| Autori: | |
| Data di pubblicazione: | 1990 |
| Rivista: | |
| Abstract: | Title ethers I [R = Ph, CH2Ph, n = 2, NR12 = NEt2, N(CHMe2)2, 1-pyrrolidinyl, piperidino, morpholino; R = Ph, CH2Ph, n = 3, NR12 = NEt3; R = CH2Ph n = 2, NR12 = NMe2; R = CH2Ph, n = 2, NR12 = piperidino] were prepd. by treating alcs. II with Cl(CH2)n NR12 and NaH in toluene. II were prepd. by the Grignard reaction of ketone III with PhMgBr of PhCH2MgCl. Some I, in particular those derived from I (R = Ph), showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid, as well as an appreciable local anesthetic activity and weak sedative effect in mice. |
| Handle: | http://hdl.handle.net/11567/379782 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
File in questo prodotto:
Copyright © 2020