Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands

The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compds. bind the A1AR in a selective way over A2AAR and A3AR and one of them presents a very high affinity, probably due to the phenethylamine substituent at C-4.

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Titolo: Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands
Autori: 
SCHENONE, SILVIA
BRUNO, OLGA
FOSSA, PAOLA
RANISE, ANGELO
MENOZZI, GIULIA
MOSTI, LUISA
BONDAVALLI, FRANCESCO
mostra contributor esterni 
Data di pubblicazione: 2001
Rivista: 
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  
Abstract: The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compds. bind the A1AR in a selective way over A2AAR and A3AR and one of them presents a very high affinity, probably due to the phenethylamine substituent at C-4.
Handle: http://hdl.handle.net/11567/246484
Appare nelle tipologie:01.01 - Articolo su rivista

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