The synthesis of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one O-[ω-(dialkylamino)alkyl]oximes by reaction of (+)-camphoroxime sodium salt with a series of ω(chloroalkyl)dialkylamines in DMF soln. is described. Some of the above compds. showed strong hypotensive, antiinflammatory, analgesic and local anesthetic activity in rats and mice, as well as moderate antiarrhythmic, antipyretic and in vitro platelet antiaggregating activity.
O-[ω-(dialkylamino)alkyl]oximes of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one with hypotensive, antiinflammatory, analgesic, local anesthetic and other activities
SCHENONE, SILVIA;BRUNO, OLGA;RANISE, ANGELO;BONDAVALLI, FRANCESCO;
1994-01-01
Abstract
The synthesis of (+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one O-[ω-(dialkylamino)alkyl]oximes by reaction of (+)-camphoroxime sodium salt with a series of ω(chloroalkyl)dialkylamines in DMF soln. is described. Some of the above compds. showed strong hypotensive, antiinflammatory, analgesic and local anesthetic activity in rats and mice, as well as moderate antiarrhythmic, antipyretic and in vitro platelet antiaggregating activity.File in questo prodotto:
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