The synthesis of 3-(arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones [I, R = (un)substituted Ph] by reaction of N-aryl-5,6-dihydro-4-hydroxy-6-methyl-2-oxo-2H-pyrano-3-carbothioamides with hydrazine is described. Some compds. showed remarkable antipyretic, analgesic, antiarrhythmic and hypotensive activity in rats or mice, as well as weak antiinflammatory, local anesthetic, and in vitro platelet antiaggregating activity.

3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities.

BRUNO, OLGA;RANISE, ANGELO;SCHENONE, SILVIA;BONDAVALLI, FRANCESCO;
1993-01-01

Abstract

The synthesis of 3-(arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones [I, R = (un)substituted Ph] by reaction of N-aryl-5,6-dihydro-4-hydroxy-6-methyl-2-oxo-2H-pyrano-3-carbothioamides with hydrazine is described. Some compds. showed remarkable antipyretic, analgesic, antiarrhythmic and hypotensive activity in rats or mice, as well as weak antiinflammatory, local anesthetic, and in vitro platelet antiaggregating activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/377755
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