IRIS
CORSARO, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 7.103
Totale 7.103
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Nazione #
IT - Italia 7.103
Totale 7.103
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Città #
Genova 5.648
Rapallo 842
Genoa 587
Bordighera 26
Totale 7.103
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Nome #
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 152
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 149
Amyloid precursor protein modulates ERK1/2 signaling 148
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 148
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 145
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 144
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 139
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 139
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 138
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates 138
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 135
Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids 131
Amyloid precursor protein and presenilin involvement in cell signaling 127
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 126
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 120
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 119
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 119
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 118
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 116
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 116
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 115
Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity 115
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 114
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 113
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 113
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 112
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 111
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 111
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 111
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 110
Role of prion protein aggregation in neurotoxicity 109
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors 106
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2 105
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 101
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 100
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 100
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 100
INTRACELLULAR MECHANISMS MEDIATING THE NEURONAL CELL DEATH AND ASTROGLIOSIS INDUCED BY THE PRION PROTEIN FRAGMENT 106-126 93
The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation 93
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 93
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 93
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 92
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 91
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 90
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 90
Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells 87
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 86
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 85
Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation 84
Cabergoline modulation of alpha-subunits and FSH secretion in a gonadotroph adenoma 84
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 83
In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas 79
Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells 77
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 73
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 72
Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 72
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro 70
The activation of the phosphotyrosine phosphatase h (r-PTPh) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 69
Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis 68
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 67
Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt 67
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 66
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 64
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 64
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 63
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 62
In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors 61
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 60
Somatostatin receptor subtype-dependent regulation of NO release: involvement of different intracellular pathways 53
The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization 52
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 51
In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas. Clin Endocrinol (Oxf). 2002 Oct;57(4):449-55. 47
New therapeutic strategies for Alzheimer’s disease by determination of structure and toxicity of oligomeric beta-amyloids aggregation states 41
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 37
Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits 28
N6-isopentenyladenosine hinders the vasculogenic mimicry in human glioblastoma cells through Src-120 catenin pathway modulation and RhoA activity inhibition 28
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 18
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 4
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 2
Prolonged treatment with α-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 1
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects 1
Totale 7.274
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Categoria #
all - tutte 18.937
article - articoli 18.109
book - libri 0
conference - conferenze 682
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 146
Totale 37.874
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019357 0 0 0 0 0 0 0 0 0 74 154 129
2019/20201.925 62 47 74 105 183 227 293 134 174 317 247 62
2020/2021555 41 58 52 40 61 39 39 58 34 57 36 40
2021/2022985 28 103 57 100 36 71 76 231 32 78 44 129
2022/2023985 71 56 11 91 166 171 3 97 148 5 154 12
2023/2024477 27 56 10 87 41 149 39 31 24 13 0 0
Totale 7.274