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EnglishBACKGROUND: Previous studies showed that the subtype 2 of somatostatin receptors (sstr2) is generally expressed by soft tissue sarcomas. MATERIALS AND METHODS: Using reverse transcription-polymerase chain reaction (RT-PCR), the present study evaluated the expression of sstr mRNA in 31 human intermediate and malignant soft tissue tumors. In 8 patients somatostatin receptor scintigraphy was performed to detect soft tissue tumor sites and visualize in vivo sstr expression. RESULTS: Somatostatin receptors were identified in 84% of the tumors analyzed by RT-PCR analysis. sstr1 and sstr2 were the receptors most frequently detected. Somatostatin receptor scintigraphy was able to identify primary and/or metastatic sites in 7 out of 8 patients, with an overall sensitivity per site of 87%. Concordant results were found between in vitro and in vivo techniques. CONCLUSION: The wide expression of sstrs in soft tissue tumors suggest a relevant role for these receptors in diagnosis and may have therapeutic applications.
In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors / Florio, Tullio; Montella, L.; Corsaro, Alessandro; De Chiara, A.; Apice, G.; Fazioli, F.; Lastoria, S.; Schettini, G.; Palmieri, G.. - STAMPA. - 23 (3B)(2003), pp. 2465-2471.
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| Titolo: | In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors |
| Autori: | |
| Data di pubblicazione: | 2003 |
| Rivista: | |
| Citazione: | In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors / Florio, Tullio; Montella, L.; Corsaro, Alessandro; De Chiara, A.; Apice, G.; Fazioli, F.; Lastoria, S.; Schettini, G.; Palmieri, G.. - STAMPA. - 23 (3B)(2003), pp. 2465-2471. |
| Handle: | http://hdl.handle.net/11567/280560 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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