IRIS
FLORIO, TULLIO
 Distribuzione geografica
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Continente #
EU - Europa 27.942
Totale 27.942
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Nazione #
IT - Italia 27.942
Totale 27.942
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Città #
Genova 20.931
Genoa 2.552
Rapallo 2.549
Vado Ligure 1.843
Bordighera 66
Totale 27.941
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Nome #
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. 192
Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects 182
The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma 175
New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells 167
Protective effects of some creatine derivatives in brain tissue anoxia. 162
Amyloid precursor protein modulates ERK1/2 signaling 161
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 157
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 156
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 156
NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion 155
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 153
Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas 153
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 153
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 153
The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells 152
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 151
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 150
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 149
Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. 149
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 148
Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA 147
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates 147
Chemokines and chemokine receptors: New actors in neuroendocrine regulations 146
Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells 143
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 141
Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer 140
SOMATOSTATIN ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASE VIA SOMATOSTATIN RECEPTOR 1 (SSTR1) 139
17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease 139
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 139
Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids 139
Amyloid precursor protein and presenilin involvement in cell signaling 137
Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors 137
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 136
Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia 136
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current 135
Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets 135
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 134
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 133
G PROTEIN ACTIVATION OF A HORMONE-STIMULATED PHOSPHATASE IN HUMAN TUMOR CELLS 132
FGFR4 polymorphism as molecular determinant of the efficacy of mTOR inhibitors in GH-secreting pituitary adenomas 132
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 131
Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma 131
Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay 130
Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment 130
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 129
Neuroblastoma: Inhibition by Alu-Like RNA 129
Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA 128
b25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells 127
Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors 127
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 127
Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases 127
Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells 127
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 126
Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures 126
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 125
Adult pituitary stem cells 125
Does pasireotide directly modulate skeletal muscle metabolism? 125
Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs? 125
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 125
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 124
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 124
Endometrial stem cells and human reproductive failure 124
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 124
The pathological prion protein forms ionic conductance in lipid bilayer 123
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 123
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 123
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 122
A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. 122
An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. 122
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 122
Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. 121
Age-related alterations of somatostatin gene expression in different rat brain areas 121
Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of Phidianidine A as a new CXCR4 ligand exhibiting antagonist activity 121
The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells 121
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors 121
Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity 121
Glioblastoma cancer stem cells: response to epidermal growth factor receptor kinase inhibitors 120
Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation 120
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 120
Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas 120
Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression 119
Chemokines and their receptors in the central nervous system 119
Differential efficacy of SSTR1, 2 and 5 agonists in the inhibition of C6 glioma growth in nude mice 119
In silico identification and experimental validation of novel anti-Alzheimer's multitargeted ligands from marine source featuring a "2-amino-imidazole plus aromatic group" scaffold 119
Isolation of a long-lasting eag-related gene type K+ current in MMQ lactotrophs and its accomodating role during slow firing and prolactin release 118
Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay 118
Role of prion protein aggregation in neurotoxicity 118
The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds 118
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 118
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 117
PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs 117
Composti e metodi per rilevare lesioni aterosclerotiche precoci in vasi sanguigni 117
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas 117
Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures 117
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 117
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 116
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study 115
A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis 115
Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. 114
An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease 114
Totale 13.262
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Categoria #
all - tutte 89.057
article - articoli 80.742
book - libri 0
conference - conferenze 3.599
curatela - curatele 0
other - altro 0
patent - brevetti 768
selected - selezionate 0
volume - volumi 3.948
Totale 178.114
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20206.071 0 0 0 0 651 824 1.119 509 636 1.201 873 258
2020/20212.227 127 175 198 177 213 216 122 179 189 302 180 149
2021/20223.670 152 380 196 401 110 262 269 814 148 282 172 484
2022/20233.137 309 199 36 308 439 555 7 248 547 42 386 61
2023/20241.986 121 214 51 239 140 386 149 122 115 58 121 270
2024/20251.978 201 461 217 534 565 0 0 0 0 0 0 0
Totale 28.752