IRIS
FLORIO, TULLIO
 Distribuzione geografica
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Continente #
EU - Europa 26.712
Totale 26.712
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Nazione #
IT - Italia 26.712
Totale 26.712
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Città #
Genova 20.931
Genoa 2.552
Rapallo 2.549
Vado Ligure 613
Bordighera 66
Totale 26.711
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Nome #
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. 189
The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma 172
Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects 164
New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells 163
Protective effects of some creatine derivatives in brain tissue anoxia. 155
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 154
NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion 153
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 153
Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas 152
Amyloid precursor protein modulates ERK1/2 signaling 151
The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells 150
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 150
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 149
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 148
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 147
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 145
Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA 145
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates 145
Chemokines and chemokine receptors: New actors in neuroendocrine regulations 143
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 143
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 142
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 141
Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. 141
Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells 140
SOMATOSTATIN ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASE VIA SOMATOSTATIN RECEPTOR 1 (SSTR1) 139
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 137
Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors 136
Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids 135
17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease 134
Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer 134
Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets 132
Amyloid precursor protein and presenilin involvement in cell signaling 131
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 131
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 131
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 130
FGFR4 polymorphism as molecular determinant of the efficacy of mTOR inhibitors in GH-secreting pituitary adenomas 130
Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia 130
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current 129
Neuroblastoma: Inhibition by Alu-Like RNA 128
G PROTEIN ACTIVATION OF A HORMONE-STIMULATED PHOSPHATASE IN HUMAN TUMOR CELLS 128
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 128
Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay 128
Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment 128
Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma 126
b25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells 125
Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors 125
Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA 124
Adult pituitary stem cells 123
Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases 123
Does pasireotide directly modulate skeletal muscle metabolism? 122
Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs? 122
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 121
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 121
Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures 121
The pathological prion protein forms ionic conductance in lipid bilayer 120
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 120
Endometrial stem cells and human reproductive failure 120
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 120
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 120
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 120
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 119
The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells 119
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 119
A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. 119
An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. 119
Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. 118
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 118
Age-related alterations of somatostatin gene expression in different rat brain areas 118
Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of Phidianidine A as a new CXCR4 ligand exhibiting antagonist activity 118
Glioblastoma cancer stem cells: response to epidermal growth factor receptor kinase inhibitors 118
Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation 118
Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity 118
Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay 117
Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells 117
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 116
Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression 116
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 116
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 116
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 116
Chemokines and their receptors in the central nervous system 115
PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs 115
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 115
Differential efficacy of SSTR1, 2 and 5 agonists in the inhibition of C6 glioma growth in nude mice 115
Isolation of a long-lasting eag-related gene type K+ current in MMQ lactotrophs and its accomodating role during slow firing and prolactin release 114
Role of prion protein aggregation in neurotoxicity 114
Composti e metodi per rilevare lesioni aterosclerotiche precoci in vasi sanguigni 114
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 114
In silico identification and experimental validation of novel anti-Alzheimer's multitargeted ligands from marine source featuring a "2-amino-imidazole plus aromatic group" scaffold 114
Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. 113
Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures 113
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 112
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors 112
Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas 112
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 112
An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease 111
The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds 111
A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis 111
The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells 110
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas 110
Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation 109
Totale 12.808
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Categoria #
all - tutte 83.091
article - articoli 75.564
book - libri 0
conference - conferenze 3.179
curatela - curatele 0
other - altro 0
patent - brevetti 712
selected - selezionate 0
volume - volumi 3.636
Totale 166.182
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20206.780 0 0 296 413 651 824 1.119 509 636 1.201 873 258
2020/20212.227 127 175 198 177 213 216 122 179 189 302 180 149
2021/20223.670 152 380 196 401 110 262 269 814 148 282 172 484
2022/20233.137 309 199 36 308 439 555 7 248 547 42 386 61
2023/20241.986 121 214 51 239 140 386 149 122 115 58 121 270
2024/2025727 201 461 65 0 0 0 0 0 0 0 0 0
Totale 27.501