IRIS
FOSSA, PAOLA
 Distribuzione geografica
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Continente #
EU - Europa 14.905
Totale 14.905
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Nazione #
IT - Italia 14.905
Totale 14.905
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Città #
Genova 11.477
Genoa 1.323
Rapallo 1.304
Vado Ligure 775
Bordighera 26
Totale 14.905
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Nome #
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 184
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 162
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 158
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 156
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 156
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 154
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 154
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 153
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 153
Modelling the interaction of steroid receptors with endocrine disrupting chemicals 151
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 150
Synthesis of 4-Thiophen-2’-yl-1,4-dihydropyridines as Potentiators of the CFTR Chloride Channel 146
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 146
1-Phenyl-1H-Indazole derivatives with analgesic and anti-inflammatory activities. 140
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 140
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 135
Chemometric study and validation strategies in the structure-activity relationships of new cardiotonic agents 135
A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla) 135
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 134
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 133
HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients 132
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 131
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 130
Discovery of a new series of 5-HT1A receptor agonists 128
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 128
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 127
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 126
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 126
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 123
Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue. 123
Structural basis for selective PDE 3 inhibition: a docking study 122
a1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-like Compounds 121
Synthesis and Cardiotonic Activity of Novel Pyrimidine Derivatives. Crystallographic and Quantum Chemical Studies 120
Activity of 3-Carbethoxyangelicin Photolysis Products 120
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 119
null 118
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 118
null 117
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 117
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 116
null 116
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 116
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 115
A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy 115
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 114
Matrine modulates HSC70 levels and rescues DF508-CFTR 114
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 114
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 112
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 112
Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1-methyl(phenyl)-1H-indazol-4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anaesthetic and analgesic agents 112
Ionization Behaviour and Tautomerism-Dependent Lipophilicity of Pyridine-2(1H)-one Cardiotonic Agents 111
Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate 111
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 110
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 110
null 108
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 107
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 107
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 106
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 105
null 104
An updated topographical model for phosphodiesterase 4 (PDE4) catalytic site 104
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 104
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 103
New arylsparteine derivatives as positive inotropic drugs 103
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 102
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 102
Synthesis and secretion of Ch 21 protein in embryonic chick skeletal tissue 102
Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone 101
Synthesis of 4-amino pyrazolo[3,4-d]pyrimidine derivatives as potential ligands for a1-adenosine receptors 100
A chemometric approach to predict A1 agonist effect of adenosine analogues 100
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 100
Synthesis and Pharmacological Characterization of Functionalized 2-Pyridones Structurally Related to the Cardiotonic Agent Milrinone 100
2- substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates: synthesis and cardiotonic activity 99
null 99
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site 98
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 97
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 97
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 96
Quinolinedione nucleus as a novel scaffold for A1 and A2A adenosine receptor antagonists. 96
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 96
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 96
4-Substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities 95
null 95
4-Substituted 1,5-diarylpyrazoles, analogues of celecoxib: synthesis and preliminary evaluation of biological properties 94
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 94
5-Substituted 4-Isoxazolecarboxamides with platelet antiaggregating and other activities 94
null 93
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies 93
Towards the identification of the cardiac cAMP phosphodiesterase receptor site 92
Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety 92
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 91
A New Milrinone analog: Role of Binding to A1 Adenosine Receptor in its Positive Inotropic Effect on Isolated Guinea Pig and Rat Atria 91
5-Substituted 4-Isoxazoleacetic acids with analgesic activity. 89
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 89
Development of a new topographical model for myocardial cGI-PDE catalytic site 88
Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by differentiating chondrocytes. 87
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies 87
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 85
New milrinone analogues:in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine and inhibition of cardiac type III phosphodiesterase 85
Totale 11.491
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Categoria #
all - tutte 46.816
article - articoli 39.587
book - libri 0
conference - conferenze 7.229
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 93.632
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.497 0 0 0 0 380 469 638 286 377 669 513 165
2020/20211.298 65 98 94 85 100 134 84 132 110 182 117 97
2021/20222.115 101 112 175 200 60 153 132 466 137 206 102 271
2022/20231.615 160 94 21 158 287 237 15 110 271 14 203 45
2023/20241.034 51 132 42 155 76 148 46 59 38 40 109 138
2024/2025835 87 219 111 234 184 0 0 0 0 0 0 0
Totale 15.335