| Nome |
# |
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A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy, file e268c4ca-0f0b-a6b7-e053-3a05fe0adea1
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264
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Modelling the interaction of steroid receptors with endocrine disrupting chemicals, file e268c4c5-ebf5-a6b7-e053-3a05fe0adea1
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120
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Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1, file e268c4c7-06dc-a6b7-e053-3a05fe0adea1
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105
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Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands, file e268c4ca-6858-a6b7-e053-3a05fe0adea1
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86
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Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles, file e268c4cc-6ece-a6b7-e053-3a05fe0adea1
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83
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Speeding up the identification of cystic fibrosis transmembrane conductance regulator-targeted drugs: An approach based on bioinformatics strategies and surface plasmon resonance, file e268c4ca-7231-a6b7-e053-3a05fe0adea1
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78
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New arylsparteine derivatives as positive inotropic drugs, file e268c4ca-6a39-a6b7-e053-3a05fe0adea1
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76
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Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation, file e268c4cc-747e-a6b7-e053-3a05fe0adea1
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62
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Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors, file e268c4c7-06ec-a6b7-e053-3a05fe0adea1
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61
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Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists, file e268c4ce-bf77-a6b7-e053-3a05fe0adea1
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55
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Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV), file e268c4ce-7292-a6b7-e053-3a05fe0adea1
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50
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Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools, file e268c4cf-14ef-a6b7-e053-3a05fe0adea1
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47
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Synthesis, antimicrobial activity and molecular modelling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles, file e268c4c5-fb23-a6b7-e053-3a05fe0adea1
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33
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Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions, file e268c4c5-f6c4-a6b7-e053-3a05fe0adea1
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25
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In silico rationalization of the structural and physicochemical requirements for photobiological activity in angelicine derivatives and their heteroanalogues, file e268c4c5-f8cd-a6b7-e053-3a05fe0adea1
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23
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Synthesis, Biological Evaluation and Molecular Modeling Studies on Benzothiadiazine Derivatives as PDE4 Selective Inhibitors, file e268c4c5-f6ca-a6b7-e053-3a05fe0adea1
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16
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New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation, file e268c4c6-14dd-a6b7-e053-3a05fe0adea1
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15
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New milrinone analogues:in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine and inhibition of cardiac type III phosphodiesterase, file e268c4c5-fc05-a6b7-e053-3a05fe0adea1
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14
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Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives., file e268c4c5-eab5-a6b7-e053-3a05fe0adea1
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12
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Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue., file e268c4ca-ecbf-a6b7-e053-3a05fe0adea1
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12
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Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells, file e268c4c6-13d5-a6b7-e053-3a05fe0adea1
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10
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Sialic acid associated to VEGFR2 of the endothelial cell surface is implicated in VEGF-dependent angiogenesis, file e268c4cb-8e90-a6b7-e053-3a05fe0adea1
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10
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EARLY ONSET DEMYELINATING CHARCOT‐MARIE‐TOOTH DISEASE CAUSED BY A NOVEL IN‐FRAME ISOLEUCINE DELETION IN PERIPHERAL MYELIN PROTEIN 2, file e268c4cb-fc51-a6b7-e053-3a05fe0adea1
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10
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Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study, file e268c4ce-bc76-a6b7-e053-3a05fe0adea1
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10
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Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone, file e268c4c5-fb2f-a6b7-e053-3a05fe0adea1
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9
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Labdane Diterpenoids from Salvia tingitana Etl. Synergize with Clindamycin against Methicillin‐Resistant Staphylococcus aureus, file e268c4ce-6f55-a6b7-e053-3a05fe0adea1
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9
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Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation., file e268c4c7-2edc-a6b7-e053-3a05fe0adea1
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8
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Rescuing defective CFTR applying a drug repositioning strategy
based on computational studies, surface plasmon resonance and
cell-based assays, file e268c4cc-ad4d-a6b7-e053-3a05fe0adea1
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7
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4-Substituted 1,5-diarylpyrazoles, analogues of celecoxib: synthesis and preliminary evaluation of biological properties, file e268c4c6-0373-a6b7-e053-3a05fe0adea1
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6
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A boron delivery antibody (BDA) with boronated specific residues: New perspectives in boron neutron capture therapy from an in silico investigation, file e268c4ce-3e50-a6b7-e053-3a05fe0adea1
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6
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Italian “Vessalico” garlic ecotype: characterization of sulfur compounds and antiviral activity against Tomato brown rugose fruit virus (ToBRFV), file 2dbf64d2-92d7-46f2-9fd9-191fc075e9ee
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5
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Synthesis and Pharmacological Characterization of Functionalized 2-Pyridones Structurally Related to the Cardiotonic Agent Milrinone, file e268c4c5-fc04-a6b7-e053-3a05fe0adea1
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5
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T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype., file e268c4c7-2edd-a6b7-e053-3a05fe0adea1
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5
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Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools, file e268c4ca-860e-a6b7-e053-3a05fe0adea1
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5
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Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors, file e268c4cc-f433-a6b7-e053-3a05fe0adea1
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5
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New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach, file e268c4cd-4c9f-a6b7-e053-3a05fe0adea1
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5
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Characterization of sulfur compounds and antiviral activity against Tomato brown rugose fruit virus (ToBRFV) of Italian “Vessalico” garlic compared to other cultivars and landrace, file 808443cc-87b6-4fae-a998-13a0456eabde
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4
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New pyrazolo[3,4-b]pyridones as selective A1 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies, file e268c4c5-f84f-a6b7-e053-3a05fe0adea1
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4
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Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study, file e268c4c5-faae-a6b7-e053-3a05fe0adea1
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4
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Affinity prediction on A1 adenosine receptor agonists: the chemometric approach, file e268c4c5-fc2b-a6b7-e053-3a05fe0adea1
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4
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New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment, file e268c4ca-5c41-a6b7-e053-3a05fe0adea1
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4
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Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine, file e268c4cb-0799-a6b7-e053-3a05fe0adea1
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4
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RESCUING DEFECTIVE CFTR APPLYING A DRUG REPOSITIONING STRATEGY, file e268c4cb-ba08-a6b7-e053-3a05fe0adea1
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4
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Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents, file e268c4ce-7687-a6b7-e053-3a05fe0adea1
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4
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Characterization of sulfur compounds and antiviral activity against Tomato brown rugose fruit virus (ToBRFV) of Italian “Vessalico” garlic compared to other cultivars and landrace, file cac41fa0-48a4-43b5-988b-e88e48bc31a1
|
3
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Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line, file e268c4c6-0060-a6b7-e053-3a05fe0adea1
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3
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A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla), file e268c4ca-55d2-a6b7-e053-3a05fe0adea1
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3
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Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics, file e268c4ca-5c3f-a6b7-e053-3a05fe0adea1
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3
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Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2, file e268c4ca-7f84-a6b7-e053-3a05fe0adea1
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3
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New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking, file e268c4ca-bb8e-a6b7-e053-3a05fe0adea1
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3
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7, file e268c4cd-2947-a6b7-e053-3a05fe0adea1
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3
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Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing, file 213099fc-8f60-4879-8157-53ad1a307642
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2
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In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein, file 595b3e73-dfc2-46a2-9664-dab64ae5df5a
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2
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Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors, file e268c4c6-124d-a6b7-e053-3a05fe0adea1
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2
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Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors., file e268c4c6-19eb-a6b7-e053-3a05fe0adea1
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2
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Docking and Molecular dynamics protocol for ligand binding characterization of Nuclear Receptors, file e268c4c8-4f62-a6b7-e053-3a05fe0adea1
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2
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Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain, file e268c4ca-04da-a6b7-e053-3a05fe0adea1
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2
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Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis, file e268c4ca-20bd-a6b7-e053-3a05fe0adea1
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2
|
|
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles, file e268c4ca-6a42-a6b7-e053-3a05fe0adea1
|
2
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Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives, file e268c4ca-a330-a6b7-e053-3a05fe0adea1
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2
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|
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists, file e268c4ca-aaa1-a6b7-e053-3a05fe0adea1
|
2
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|
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties., file e268c4ca-baaa-a6b7-e053-3a05fe0adea1
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2
|
|
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists, file e268c4ca-c373-a6b7-e053-3a05fe0adea1
|
2
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|
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies, file e268c4cb-05c0-a6b7-e053-3a05fe0adea1
|
2
|
|
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors, file e268c4cb-1c1f-a6b7-e053-3a05fe0adea1
|
2
|
|
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies, file e268c4cb-1e42-a6b7-e053-3a05fe0adea1
|
2
|
|
Studi strutturistici sulla proteina CFTR: opportunità e prospettive, file e268c4cb-8e92-a6b7-e053-3a05fe0adea1
|
2
|
|
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction, file bdb4b699-6fdb-4eee-9563-419e36ec2a3c
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1
|
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Discovery of a new series of 5-HT1A receptor agonists, file e268c4c5-f169-a6b7-e053-3a05fe0adea1
|
1
|
|
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation, file e268c4c5-f237-a6b7-e053-3a05fe0adea1
|
1
|
|
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis, file e268c4c5-f7b4-a6b7-e053-3a05fe0adea1
|
1
|
|
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation, file e268c4c6-06c8-a6b7-e053-3a05fe0adea1
|
1
|
|
Synthesis of 4-Thiophen-2’-yl-1,4-dihydropyridines as Potentiators of the CFTR Chloride Channel, file e268c4c6-13b1-a6b7-e053-3a05fe0adea1
|
1
|
|
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study, file e268c4ca-9fe8-a6b7-e053-3a05fe0adea1
|
1
|
|
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists, file e268c4ca-ba9f-a6b7-e053-3a05fe0adea1
|
1
|
|
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5, file e268c4cb-079c-a6b7-e053-3a05fe0adea1
|
1
|
|
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands, file e268c4cb-1834-a6b7-e053-3a05fe0adea1
|
1
|
|
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold, file e268c4cb-1c24-a6b7-e053-3a05fe0adea1
|
1
|
|
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists, file e268c4cb-1dd7-a6b7-e053-3a05fe0adea1
|
1
|
|
Structure-Activity Relationships within a Series of sigma1 and sigma2 Receptor Ligands: Identification of a sigma2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma, file e268c4cb-1ffe-a6b7-e053-3a05fe0adea1
|
1
|
|
Recent updates in CFTR structural studies: opportunities and challenges for cystic fibrosis drug development, file e268c4cb-8e8e-a6b7-e053-3a05fe0adea1
|
1
|
|
Multidisciplinary approaches to rescue CFTR impairments by drug repositioning, file e268c4cb-ba0a-a6b7-e053-3a05fe0adea1
|
1
|
|
Identification of a Potent and Selective 5-HT1A Receptor Agonist with In Vitro and In Vivo Antinociceptive Activity., file e268c4cd-4d92-a6b7-e053-3a05fe0adea1
|
1
|
|
Exploring the selectivity profile of sigma receptor ligands by molecular docking and pharmacophore analyses., file e268c4cd-7666-a6b7-e053-3a05fe0adea1
|
1
|
|
In silico drug repositioning on F508del-CFTR: a proof-of concept study on the AIFA library, file e268c4cd-9ea4-a6b7-e053-3a05fe0adea1
|
1
|
| Totale |
1.455 |