IRIS
THELLUNG DE COURTELARY, STEFANO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 8.145
Totale 8.145
Salva come PNG Salva come JPEG
Nazione #
IT - Italia 8.145
Totale 8.145
Salva come PNG Salva come JPEG
Città #
Genova 6.524
Rapallo 897
Genoa 696
Bordighera 27
Totale 8.144
Salva come PNG Salva come JPEG
Nome #
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 152
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 149
Amyloid precursor protein modulates ERK1/2 signaling 148
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 148
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 145
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 145
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 144
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 139
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 139
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 138
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 136
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 135
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 127
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 127
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 127
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 126
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 119
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 119
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 118
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 116
Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation 116
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 116
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 115
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 114
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 113
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 113
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 112
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 111
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 111
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 111
Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. 110
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 110
In silico identification and experimental validation of novel anti-Alzheimer's multitargeted ligands from marine source featuring a "2-amino-imidazole plus aromatic group" scaffold 110
Role of prion protein aggregation in neurotoxicity 109
In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism 106
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2 105
Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential 104
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 101
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 100
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 100
Molecular mechanisms mediating neuronal cell death in experimental models of prion diseases, in vitro 100
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 100
Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms 97
INTRACELLULAR MECHANISMS MEDIATING THE NEURONAL CELL DEATH AND ASTROGLIOSIS INDUCED BY THE PRION PROTEIN FRAGMENT 106-126 93
CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis 93
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 93
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 93
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 92
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 91
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 91
TGF-beta1 prevents gp120-induced impairment of Ca++ homeostasis and rescues cortical neurons from apoptotic death 90
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 90
Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells 87
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 86
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 85
Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation 84
A. novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced cytosolic Ca2+ rise 84
Consensus based recommendations for diagnosis and medical management of Poland syndrome (sequence) 84
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 83
Oncogene transformation of PC Cl3 clonal thyroid cell line induces an autonomous pattern of proliferation that correlates with a loss of basal and stimulated phosphotyrosine phosphatase activity 82
Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells 77
Effect of nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes. Neurochem. Research 75
Intracellular transducing mechanisms modulated by activated brain somatostatin receptors 73
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 73
Synthesis of guanidinoacetate and creatine in neurons and glial cells 72
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 72
Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 72
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 72
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro 70
The activation of the phosphotyrosine phosphatase h (r-PTPh) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 69
Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis 68
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 67
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 66
Nitric Oxide and GABAA Receptor Function in the Rat Cerebral Cortex and Cerebellar Granule Cells. 64
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 64
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 64
Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization 64
MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment 64
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 63
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 62
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 60
Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies 59
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 53
Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity 37
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 37
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 33
Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues 22
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 18
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 4
Bioinspired nanoparticles for glioblastoma treatment 4
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 2
Prolonged treatment with α-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 1
Totale 8.383
Salva come PNG Salva come JPEG
Categoria #
all - tutte 22.905
article - articoli 21.877
book - libri 0
conference - conferenze 595
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 433
Totale 45.810
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019345 0 0 0 0 0 0 0 0 0 0 186 159
2019/20202.181 74 50 75 130 208 269 329 172 196 347 258 73
2020/2021798 50 86 76 64 87 58 48 72 56 104 52 45
2021/20221.107 35 102 62 119 36 87 87 249 41 86 53 150
2022/20231.064 91 63 9 107 168 183 1 95 170 6 156 15
2023/2024566 45 71 16 90 45 151 44 40 28 24 12 0
Totale 8.383