IRIS
PIETRA, GABRIELLA
 Distribuzione geografica
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Continente #
EU - Europa 7.816
Totale 7.816
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Nazione #
IT - Italia 7.816
Totale 7.816
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Città #
Genova 6.456
Rapallo 765
Genoa 590
Bordighera 5
Totale 7.816
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Nome #
Identification of cytomegalovirus (CMV)-specific T lymphocytes displaying an effector-memory phenotype that kill CMV-infected target cells in an HLA-E-restricted fashion 171
Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function 163
Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment 142
Detection of MAGE-1, -2, and -3 messenger RNA in tissue samples derived from lung and mammary tumors. 136
Effect of tumor cells and tumor microenvironment on NK-cell function. 135
Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias 134
Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor 130
Human NK Cells: From Surface Receptors to the Therapy of Leukemias and Solid Tumors. 125
Detection of oligoclonal T lymphocytes in lymph nodes draining from advanced non-small-cell lung cancer. 124
Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function 124
Intensified chemotherapy supported by DMSO-free peripheral blood progenitor cells in breast cancer patients. 120
Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts 118
Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK cell function 117
NK-cell editing mediates epithelial-to-mesenchymal transition via phenotypic and proteomic changes in melanoma cell lines 117
Role of major histocompatibility complex class I expression and natural killer-like T cells in the genetic control of endometriosis. 115
Infusion of in vitro expanded tumour-infiltrating lymphocytes and recombinant interleukin-2 in patients with surgically resected lymph node metastases of malignant melanoma: a pilot study. 113
HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes. 112
Natural killer cells lyse autologous herpes simplex virus infected targets using cytolytic mechanisms distributed clonotypically. 111
How melanoma cells inactivate NK cells 109
The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors. 109
Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages 108
Comparative analysis of NK- or NK-CTL-mediated lysis of immature or mature autologous dendritic cells 107
Adherent neoplastic cells grown at confluence downregulate HLA class I expression and enhance their susceptibility to lysis mediated by natural killer cells. 107
Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma. 107
Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells. 107
Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition 106
NK-CTLs, a novel HLA-E-restricted T-cell subset 105
Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines 104
Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surface in the context of HLA-E 104
Structural basis for a major histocompatibility complex class Ib-restricted T cell response 103
Natural killer cells kill human melanoma cells with characteristics of cancer stem cells. 102
Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC. 102
alpha-Interferon treatment induces quantitative modifications of HLA class I-associated peptides eluted from cultured cancer cell lines 101
Interaction between novel anticancer agents and radiation in non-small cell lung cancer cell lines. 99
Human NK cells: From surface receptors to clinical applications 99
HLA-E-restricted recognition of human cytomegalovirus by a subset of cytolytic T lymphocytes 99
HO-1 downregulation favors BRAFV600 melanoma cell death induced by Vemurafenib/PLX4032 and increases NK recognition 99
Quantitative flow cytometric analysis of the effects of cetirizine on the expression of ICAM-1/CD54 on primary cultured nasal cells. 98
Hypoxia modifies the transcriptome of human NK cells, modulates their immunoregulatory profile, and influences NK cell subset migration 98
Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. 97
Proliferative, phenotypic and functional and molecular characteristics of tumour-infiltrating lymphocytes obtained from unselected patients with malignant melanomas and expanded in vitro in the presence of recombinant interleukin-2 94
Melanoma immunoediting by NK cells. 94
Role of NK cells in immunotherapy and virotherapy of solid tumors 94
Melanoma cells inhibit NK cell functions-response 93
Effect of Melanoma-derived Fibroblasts on NK Cell Phenotype and Functions 93
Influence of Vitamin D in Advanced Non-Small Cell Lung Cancer Patients Treated with Nivolumab 93
Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity 92
Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation 90
Isolation, Expansion, and Characterization of Natural Killer Cells and Their Precursors as a Tool to Study Cancer Immunosurveillance 90
The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition 89
Human natural killer cells and other innate lymphoid cells in cancer: Friends or foes? 86
Normal epithelial cells modulating HLA class I surface molecules are susceptible to lysis mediated by CD3(+) and CD3(-) "nonspecific" killer cells. 85
Limiting dilution analysis of peripheral blood lymphocytes reacting with non-small-cell lung cancer: functionally heterogeneous effectors efficiently lyse autologous cancer cells. 85
Morphological, phenotypic and karyotypic characterization of a novel natural-killer-cell target - evidence of involvement of MHC class-I molecules in NK cell recognition. 84
Immune Checkpoint Inhibitors: Anti-NKG2A Antibodies on Board 84
A new mechanism of resistance to NK cell attack in melanoma 81
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells 80
Human cytolytic T lymphocytes expressing HLA class I-specific inhibitory receptors 79
A conserved energetic footprint underpins recognition of Human Leukocyte Antigen-E by two distinct αβ T cell receptors 78
MELANOMA CELLS INTERFERE WITH THE ACTIVITY OF NK CELLS BY MODULATING THEIR PHENOTYPE AND CYTOTOXIC FUNCTION 75
L19-IL2 immunocytokine in combination with the anti-syndecan-1 46F2SIP antibody format: A new targeted treatment approach in an ovarian carcinoma model 75
Melanoma cells inhibit natural killer cell function by modulating their phenotype 73
Dendritic cell maturation is inhibited by apoptotic bodies and promoted by necrotic cells from human melanoma 69
Heterogeneity of the alpha-interferon-mediated overexpression of class-I and class-II major histocompatibility complex molecules in primary cultured cancer cells. 67
In vitro effects of loratadine and its active metabolite an T lymphocytes 65
Hla-E-Restricted Cytolytic T Lymphocytes: Their Role in Cytomegalovirus Infection and Transplantation 65
Characterization of metabolic and molecular response of a human melanoma cell line resistant to PLX4032 64
Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzymes peroxiredoxin 5 60
Natural Killer Cell Effector Mechanisms Against solid tumors and leukemias and their exploitation in immunotherapy 60
EXPRESSION OF KILLER INHIBOTORY RECEPTOR (KIR) CD158B ON RESIDUAL TCRalpha/beta or gamma/delta T CELLS ON B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL) MODULATE THEIR CYTOTOXIC ACTIVITY 59
The engagement of ctla-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and tnf-alpha production. 58
Polymorphism in human cytomegalovirus UL40 impacts on recognition of HLA-E by natural killer cells. 58
The role of peptide in the recognition of HLA-E by cytomegalovirus-specific CD8+T cells 56
RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION 55
HLA-E and HLA-E-bound peptides: recognition by subsets of NK and T cells. 55
Exploiting Human NK Cells in Tumor Therapy 55
Recognition of the non-classical MHC class I molecule, HLA-E, by the adaptive immune system 53
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28 53
NK CELL AND TUMOR MICROENVIRONMENT INTERACTIONS IN MELANOMA 52
Phenotipic and Functional Characterization of Human Decidual Natural Killer Cells 51
Adoptive immunotherapy with tumor-infiltrating lymphocytes and subcutaneous recombinant interleukin-2 plus interferon alfa-2a for melanoma patients with nonresectable distant disease: a phase I/II pilot trial. Melanoma Istituto Scientifico Tumori Group. 51
Human dendritic cells (DCs) efficiently internalize apoptotic bodies from vaccinia virus infected non Hodgkin lymphoma (NHL) cells. 46
Association Between Response to Nivolumab Treatment and Peripheral Blood Lymphocyte Subsets in Patients With Non-small Cell Lung Cancer 41
Targeted therapies: Friends or foes for patient's NK cell-mediated tumor immune-surveillance? 39
Phases of apoptosis of melanoma cells, but not of normal melanocytes, differently affect maturation of myeloid dendritic cells. 38
Titolo BOOK Chapter: NK cell effector mechanisms against solid tumors and leukemias and their exploitation in immunotherapy. Cancer Immunotherapy Principles and Practice, edited by Lisa H. Butterfield, PhD, Howard L. Kaufman, MD, FACS, and Francesco M. Marincola, MD, FACS, (Volume Editors). 34
Interleukin-15 and cancer: Some solved and many unsolved questions 34
PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism 25
NK cells and ILCs in tumor immunotherapy 24
Whole-Exome Sequencing and cfDNA Analysis Uncover Genetic Determinants of Melanoma Therapy Response in a Real-World Setting 22
TIGIT Blockade and IL15 in Tumor Immunotherapy: Together is Better 21
Immune Checkpoint Blockade: A Strategy to Unleash the Potential of Natural Killer Cells in the Anti-Cancer Therapy 16
HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAFV600E Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia 16
Vitamin D plasma level can affect nivolumab drug exposure in a cohort of patients with non-small-cell lung cancer 16
Natural killer cell receptors regulate responses of HLA-E-restricted T cells 16
Immune Checkpoint Blockade: A Strategy to Unleash the Potential of Natural Killer Cells in the Anti-Cancer Therapy 13
Murine models to study human NK cells in human solid tumors 12
The roles of different forms of IL-15 in human melanoma progression 10
Totale 7.993
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Categoria #
all - tutte 20.516
article - articoli 20.025
book - libri 171
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 320
Totale 41.032
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019457 0 0 0 0 0 0 0 0 0 0 251 206
2019/20202.363 119 67 98 147 241 246 319 171 208 401 266 80
2020/2021744 41 52 96 54 33 69 43 59 84 80 80 53
2021/20221.072 16 81 87 96 47 76 73 261 59 104 47 125
2022/2023926 99 56 13 78 176 170 0 66 157 3 93 15
2023/2024447 30 63 19 84 62 107 23 20 20 17 2 0
Totale 7.993