IRIS
TONETTI, MICHELA
 Distribuzione geografica
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Continente #
EU - Europa 7.803
Totale 7.803
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Nazione #
IT - Italia 7.803
Totale 7.803
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Città #
Genova 6.158
Rapallo 817
Genoa 664
Vado Ligure 153
Bordighera 11
Totale 7.803
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Nome #
A novel dimeric fluoropyrimidine molecule behaves as a remote precursor of 5-Fluoro-2'-deoxyuridine in human erythrocytes. 133
Differential role of NADP+ and NADPH in the activity and structure of GDP-D-mannose 4,6-dehydratase from two chlorella viruses 128
Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients 124
Enhanced antitumor activity of adriamycin by encapsulation in mouse erythrocytes targeted to liver and lungs. 122
The Autonomous Glycosylation of Large DNA Viruses 122
Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses 120
N-linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent 117
Fucose supplementation in LAD II 116
Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model 116
Leukocyte adhesion deficiency (LAD) type II/carbohydrate deficient glycoprotein (CDG)IIc-founder effect and genotype/phenotype correlation 114
Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells 113
Chloroviruses have a sweet tooth 113
Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients 112
Characterization of a UDP-N-acetylglucosamine biosynthetic pathway encoded by the giant DNA virus Mimivirus 111
Differential role of NADP+ and NADPH in the activity and structure of GDP-D-mannose 4,6-dehydratase from two chlorella viruses 110
Synthesis of GDP-L-Fucose by the Human FX protein 109
Multiple small molecular weight guanine nucleotide-binding proteins in human erythrocyte membranes 109
Use of glutaraldehyde treated autologous human erythrocytes for hepatic targeting of doxorubicin. 109
Synergistic Cytotoxicity of Carboplatin and Divicine on Murine Erythroleukemic Cells 108
Giant virus Megavirus chilensis encodes the biosynthetic pathway for uncommon acetamido sugars 107
Enhanced intracellular activation of carboplatin in hemoglobin-synthesizing versus undifferentiated erythroleukemic cells 107
Structure of N-linked oligosaccharides attached to chlorovirus PBCV-1 major capsid protein reveals unusual class of complex N-glycans 106
Leukocyte Adhesion Deficiency 105
Probing the catalytic mechanism of GDP-4-keto-6-deoxy-D-mannose epimerase/reductase by kinetic and crystallographic characterization of site specific mutants 103
Core fucosylation of N-linked glycans in leukocytes adhesion deficiency/congenital disorder of glycosylation IIc fibroblasts 102
Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-D-glucose (Viosamine). 102
The rare sugar N-acetylated viosamine is a major component of Mimivirus fibers 102
Paramecium bursaria Chlorella Virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose 102
Expression, Purification and Characterization of GDP-D-Mannose 4,6-Dehydratase from Escherichia Coli 101
Enhanced formation of reactive species from cis- diammine (1,1-cyclobutane-dicarboxylato) platinum (II) (Carboplatin) in the presence of oxygen free radicals 101
Carbohydrates: Translation from sticky to sweet 97
Occurence in human cells of a metabolic pathway converting dTDP-D-glucose to 6-deoxyhexoses 96
The N-glycan structures of the antigenic variants of chlorovirus PBCV-1 major capsid protein help to identify the virus-encoded glycosyltransferases 96
Biophysical Approaches to Solve the Structures of the Complex Glycan Shield of Chloroviruses 94
Defective intracellular activity of GDP-D-mannose 4,6 dehydratase in leukocytes adhesion deficiency Type II (LAD II) syndrome. 92
Quartz dissolution by the sponge Chondrosia reniformis (Porifera, Demospongiae) 92
Kinetic and Crystallographic Analises Support a Sequential-ordered Bi Bi Catalytic Mechanism for Escherichia Coli Glucose-1-Thymidyltransferase. 91
Human Red Blood Cells (RBC) as Bioreactors for the Production and the Release of Fluoropyrimidine Drugs from Encapsulated Pro-Drugs 89
Cloning and expression of two enzymes involved in the de novo synthesis of GDP-L-fucose in PBCV-1 88
Cloning and expression of the human NADP(H)-binding protein FX 87
Encapsulation of Glucose Oxidase in mouse erythrocytes :an experimental model of oxidant-induced cytotoxicity and a means for splenic targeting of carrier erythrocytes. 87
Engineered erythrocytes as carriers and bioreactors for biomedical research 86
Quaternary assembly and crystal structure of GDP-D-mannose 4,6 dehydratase from Paramencium bursaria Chlorella virus 84
In vitro reconstruction of the complete metabolic pathway that converts GDP-D-mannose to GDP-L-fucose in bacterial cells. 83
Effect of defective import of GDP-fucose into Golgi apparatus on glycoconjugates composition in cells from LAD II patient 83
Defective intracellular activity of GDP-D-mannose 4,6 dehydratase in leukocyte adhesion deficiency type II (LAD II) 81
Identification of the molecular basis of leukocytes adhesion deficiency Type II (LAD II) syndrome 81
Preliminary structural characterization of recombinant GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from E.coli 80
In vivo liver and lung targeting of adriamycin encapsulated in glutaraldehyde-treated murine erythrocytes. 80
Characterization of the residual fucose-containing glycoconjugates in LAD II/CDGS IIc cells 79
Core fucosylation of N-linked glycans in Lad II Cdg IIc fibroblasts 78
Tissue Specific Transplantation Antigen P35B (= GDP-4-keto-6-D-Deoxymannose Epimerase-Reductase) (TSTA3) 77
The glycosyaltion in nucleo-cytoplasmic large DNA viruses (NVLDV) 76
Use of mass spectrometry to characterize the products of two enzymes encoded by Chlorella Virus PBCV-1 75
Extracellular ATP Potentiates Nitric Oxide Synthase Expression Induced by Lipopolysaccharide in Raw 264.7 Murine Macrophages 74
Time -dependent normalization of defective Slex expression and GDP-mannose 4,6 dehydratase (GMD) activity in long-term culture of lymphocytes from a LAD II patients. 74
The Chlorella virus PBCV-1 encodes two enzymes involved in the de novo synthesis of GDP-L-fucose and GDP-D-rhamnose 73
Primary structure,cDNA sequence and tissue localization of the human NADP-binding protein FX. 72
Engineered Erythrocytes as Biotechnological Tools for Advanced Therapies 72
Engineered erythrocytes as carriers and bioreactors. 72
Synthesis and characterization of a specific peptide nuclei acid that inhibits expression of inducible NO synthase 71
GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from E. coli, a key enzyme in the biosynthesis of GDP-L-fucose displays the strucutral characteristics of the RED protein homology superfamily 70
Structural and enzymatic characterization of human recombinant GDP-D-mannose 4,6 dehydratase 69
Liver targeting of autologous erythrocytes loaded with doxorubicin 67
Effects of the murine L929 and L1210 cell lines on nitric oxide and TNFalfa production by RAW 264.7 murine macrophages. 66
Differential terminal fucosylation of N-Linked glycans versus protein O-Fucosylation in Leukocyte Adhesion Deficiency Type II (CDG IIc) 66
The high resolution structure of GDP-4-keto-6-deoxy-D-mannose epimerase/reductase. 66
Human and Murine Erythrocytes as Bioreactors releasing the antineoplastic drug 5-fluoro-2'-deoxyuridine. 65
Structural and enzymatic characterization of recombinant GDP-D-mannose dehydratase (GMD) from PBCV-1 virus 64
Structural and enzymatic characterization of recombinant GDP-D-mannose dehydratase (GMD) from PBCV-1 virus. 64
The defect of the Golgi GDP-L-fucose transporter IIc:effect on GDP-L-fucose metabolism. 64
Differential terminal fucosylation of N-Linked glycans versus protein O-Fucosylation in Leukocyte Adhesion Deficiency Type II (CDG IIc). 64
The NADP(H)-binding protein FX is an enzyme involved in the synthesis of GDP-L-fucose. 64
Differential terminal fucosylation of N-Linked glycans versus protein O-Fucosylation in Leukocyte Adhesion Deficiency Type II (CDG IIc) 64
Structural and enzymatic characterization of recombinant GDP-D-mannose dehydratase (GMD) from PBCV-1 virus 62
Chlorella Virus PBCV-1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose 61
Core fucosylation of glycoprotein in LAD II/CDGs IIc fibroblasts 60
GDP-L-fucose metabolism in fibroblasts from LAD II/CDG IIc patients. 60
Identification of a metabolic pathway able to convert dTDP-D-glucose to 6-deoxyhexoses in human cells 60
The metabolism of 6-deoxhexoses in bacterial and animal cells 58
Interaction of carboplatin with carrier human erythrocytes 57
The chlorella virus PBCV-1 encodes two enzymes involved in the de novo synthesis of GDP-L-fucose. 56
Glucose 6-phosphate dehydrogenase from human erythrocytes: identification of N-acetil-alanine at the N-terminus of the mature protein 55
Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans 54
Extracellular ATP enhances mRNA levels of nitric oxide synthase and TNF-a in lipopolysaccharide-treated RAW 264.7 murine macrophage 53
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced b indoleamine 2,3-dioxgenase 53
Interactions of carboplatin with human erythrocytes and murine erythroleukemic cells. 53
Le comunità di pratica presso l’Università di Genova: l’esperienza e le motivazioni dei partecipanti 53
Analisi strutturale degli oligosaccaridi N-linked e O-linked contenenti fucoso nelle glicoproteine di pazienti affetti da sindrome LAD II 51
Effects of microRNAs on fucosyltransferase 8 expressio in hepatocarcinoma cells 50
Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. 50
Structural and enzymatic characterization of recombinant GDP-D-mannose dehydratase (GMD) from PBCV-1 virus. 47
Identification of cis-diamminedichloroplatinum adducts with DNA by HPLC and mass Spectrometry 45
Come avviare un programma di Faculty Development: l’esperienza dell’Università di Genova 33
Il corso di formazione all’innovazione didattica universitaria (FOR.I.U.) dell’Università di Genova 31
Expanding the Occurrence of Polysaccharides to the Viral World: The Case of Mimivirus 16
Unraveling the pathogenic bases of Catel-Manzke syndrome using a zebrafish knock-out model 3
Totale 7.878
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Categoria #
all - tutte 21.921
article - articoli 15.984
book - libri 0
conference - conferenze 4.181
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 1.756
Totale 43.842
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.919 0 0 134 89 159 209 288 96 174 395 250 125
2020/2021433 18 36 21 26 48 34 31 38 52 60 32 37
2021/20221.111 30 87 84 132 41 54 78 273 29 96 41 166
2022/20231.010 117 54 10 99 175 191 0 82 182 4 84 12
2023/2024465 27 89 17 47 35 91 24 27 15 8 16 69
2024/2025177 43 118 16 0 0 0 0 0 0 0 0 0
Totale 7.878