IRIS
CICHERO, ELENA
 Distribuzione geografica
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Continente #
EU - Europa 8.019
Totale 8.019
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Nazione #
IT - Italia 8.019
Totale 8.019
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Città #
Genova 5.848
Genoa 844
Rapallo 720
Vado Ligure 592
Bordighera 15
Totale 8.019
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Nome #
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 184
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 163
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 158
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 156
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 156
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 154
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 154
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 153
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 153
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 150
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 146
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 144
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 140
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 137
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 134
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 134
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 132
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 130
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 128
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 127
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 119
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 119
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 119
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 117
null 116
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 116
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 115
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 115
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 114
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 114
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 112
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 110
null 108
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 108
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 108
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 107
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 104
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 103
New arylsparteine derivatives as positive inotropic drugs 103
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 102
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 101
null 99
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study 98
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 98
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 97
null 95
Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays 89
Speeding up the identification of cystic fibrosis transmembrane conductance regulator-targeted drugs: An approach based on bioinformatics strategies and surface plasmon resonance 85
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 82
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic alpha1- and 5-HT1A receptors. 81
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 81
Scouting new molecular targets for CFTR therapy: the HSC70/BAG-1 complex. A computational study. 80
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 80
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as potential potentiators of the chloride transport defect in cystic fibrosis 79
null 76
Structure-Activity Relationships within a Series of sigma1 and sigma2 Receptor Ligands: Identification of a sigma2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 75
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 75
Homology modeling, docking studies and molecular dynamic simulations using GPU architecture to probe the type-11 Phosphodiesterase (PDE11) catalytic site: a computational approach for the rational design of selective inhibitors. 69
Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modeling and docking studies. 67
Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation 67
null 66
Opportunities and challenges in the design of selective TAAR1 agonists: an editorial 60
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 59
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 58
null 55
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 55
Targeting species-specific TAAR1 ligands: to date perspective of the rational drug design process 50
Recent strategic advances in CFTR drug discovery: an overview 49
Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays 47
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 46
In silico drug repositioning on F508del-CFTR: a proof-of concept study on the AIFA library 43
Virtual Screening in the Identification of Sirtuins' Activity Modulators 41
New insights into the structure of the Trace Amine-Associated Receptor 2 (TAAR2): homology modeling studies exploring the binding mode of 3-iodothyronamine 41
RESCUING DEFECTIVE CFTR APPLYING A DRUG REPOSITIONING STRATEGY 41
Pharmacophore and pharmacokinetic filtering tools guiding for the design and synthesis of novel thiazole-containing and VX-809 hybrid derivatives as F508del correctors. 40
Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators 39
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 38
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 38
Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network 37
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 35
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present) 35
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis 35
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma 32
Identification of a Potent and Selective 5-HT1A Receptor Agonist with In Vitro and In Vivo Antinociceptive Activity. 29
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 28
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 27
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 26
Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents 24
In silico exploration of LANCL2-ABA binding mode towards the identification of novel LANCL2 agonists 23
Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies 20
New pyrazolyl thioureas active against the Staphylococcus genus 19
null 18
In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein 17
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists 16
IN SILICO INVESTIGATION OF LANCL-2 ACTIVATION MECHANISM: THE CASE OF BT-11 (OMILANCOR). 16
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 15
Computational studies of the LANCL2 protein and abscissic acid towards the discovery of new ligands 15
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 14
Structure-Based Virtual Screening (SBVS) in flexible systems: the case of SIRT-2 14
Totale 8.303
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Categoria #
all - tutte 27.703
article - articoli 26.421
book - libri 0
conference - conferenze 1.282
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 55.406
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.790 0 0 0 0 210 242 319 185 209 320 239 66
2020/20211.010 49 57 86 97 39 105 71 108 68 161 118 51
2021/20221.144 53 22 109 96 31 101 55 226 89 110 77 175
2022/2023882 85 45 16 83 165 124 1 76 157 11 97 22
2023/2024688 26 76 31 98 37 78 31 50 38 34 84 105
2024/2025669 90 128 120 165 166 0 0 0 0 0 0 0
Totale 8.379