Sinthesis in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)-coumarins

Pursuing our chemical and biological studies in this field, we described the multistep preparation of the new 5-, 6-, or 7-alkoxy and 7-alkoxy-8-methyl substituted 4-(1-piperazinyl)coumarins 5d-v, as well as the in vitro evaluation of their inhibitory activity on human platelet aggregation induced in platelet-rich plasma by ADP, collagen or the Ca2+ ionophore A23187. Compounds 5h-j,p,r-u showed notably high activity towards all the platelet aggregation inducers used, and the most active one, 8-methyl-4-(1-piperazinyl)-7-(3- pyridylmethoxy)coumarin (5t), proved to be a potent in vitro antiplatelet agent.

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Titolo: Sinthesis in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)-coumarins
Autori: 
DI BRACCIO, MARIO
GROSSI, GIANCARLO
ROMA, GIORGIO
SIGNORELLO, MARIA GRAZIA
LEONCINI, GIULIANA
Data di pubblicazione: 2004
Rivista: 
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  
Handle: http://hdl.handle.net/11567/214403
Appare nelle tipologie:01.01 - Articolo su rivista

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