Distribuzione geografica
Continente #
EU - Europa 6.960
Totale 6.960
Nazione #
IT - Italia 6.960
Totale 6.960
Città #
Genova 5.450
Rapallo 842
Genoa 658
Bordighera 10
Totale 6.960
Nome #
Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients 154
Role of the calpain-calpastatin system in the density-dependent growth arrest 150
A2A-D2 heteromers on striatal astrocytes: Biochemical and biophysical evidence 150
Clinical Severity of β-thalassaemia/Hb E Disease Is Associated with Differential Activities of the Calpain-Calpastatin Proteolytic System. 146
Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR. 146
Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients 144
Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment 143
Involvement of exon 6-mediated calpastatin intracellular movements in the modulation of calpain activation. 139
Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients. 138
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle. 137
Autolysis of human erythrocytes calpain produces two active enzyme forms with different cell localization 135
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. 133
Pathological role of the calpain/calpastatin system in cystic fibrosis 128
Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90. 126
Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin 126
Characterization of the calpain/calpastatin system in human hemopoietic cell lines 126
Regulation of calpain activity in rat brain with altered Ca2+ homeostasis 125
Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells. 125
Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis. 122
Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain. 121
A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation 120
Acyl-CoA-binding protein is a potent m-calpain activator 117
Degradation of CFTR-generated protein clusters by calpain: A physiological or a pathological role? 114
Cell protection from Ca2+-overloading by bioactive molecules extracted from olive pomace 114
Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons. 112
Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease. 110
“In vivo degradation of Nitric-Oxide Synthase isozymes by Calpain is regulated by HSP90” 110
The calpain-calpastatin system in cystic fibrosis: physiopathological implications 109
Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein. 109
“Susceptibility of NOS isoforms to calpain digestion is modulated by the expression levels of HSP90” 108
Role of calpain-1 in the early phase of experimental ALS 108
Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover 108
Changes in intracellular localization of calpastatin during calpain activation 103
Age-dependent degradation of calpastatin in kidney of hypertensive rats 96
Changes in intracellular calpastatin localization are mediated by reversible phosphorylation 95
Role of the regulatory domain of calpastatin in the autoproteolytic activation of calpain 95
Is the Expression of [-G93A(+)] human SOD1 a model to study neurodegenerations? 92
Phosphorylation of rat brain calpastatins by protein kinase C. 91
In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex 89
"Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease?" 87
Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells 86
Modulation of rat brain calpastatin efficiency by post-translational modifications 82
Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells. 81
Properties of calpastatin forms in rat brain 80
Regulation of the calpain-calpastatin system in rat brain during alteration of Ca2+ homeostasis 78
“Involvement of the Calpain/Calpastatin System in Familial Amyotrophic Lateral Sclerosis” 78
Cytosolic levels of calpastatin are regulated by limited proteolysis 78
Activation of calpain 1 and protein kinase C alpha promotes a constitutive expression and release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients 76
“Regulation of calpain activity in brain following altered Ca2+ homeostasis” 74
Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis 73
A Bioactive Olive Pomace Extract Prevents the Death of Murine Cortical Neurons Triggered by NMDAR Over-Activation 73
"Cytosolic levels of calpastatin are regulated by limited proteolysis" 71
“How is alteration in Ca2+ homeostasis controlled in brain? A role for calpastatin” 70
A Novel signalling mechanism promoting Ca(2+) driven cell responses through high-mobility group box-1/NMDA receptor interaction. 69
Production and purification of recombinant calpastatin 69
Isolation of endogenous calpastatin 67
Bioactive molecules isolated from olive pomace extract protect cells from calcium mediated damages 66
Principi di biochimica 62
"Intracellular calpastatin proteolysis: a salvage mechanism or a prelude to cell damage?" 60
Biochemical and biophysical evidence for the A2A-D2 heteroreceptors in striatal astrocytes 59
Specific role of calpain-1 associated to N-methy l-D-aspartate receptor in lipid rafts microdomains 58
Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease? 57
Interaction between catalitically inactive calpain and calpastatin: evidence for its occurrence in stimulated cells 56
Biochimica 55
Immunoblotting for calpastatin expression 55
Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells 52
“Entry in the quiescent G0 cell state requires enhanced calpain activation” 51
Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes 50
The calpain-calpastatin system in human central nervous system tumours: new insight on its prognostic value 50
Homozygous familial hypercholesterolemia in Italy: Clinical and molecular features 50
A2A-D2 heteromerization on striatal astrocytes: evidence and modulation of glutamate release 45
Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes 41
Identification of potential leukocyte biomarkers related to drug recovery of cftr: Clinical applications in cystic fibrosis 40
Reactive astrocytosis in a mouse model of chronic polyamine catabolism activation 40
Revisiting the role of leukocytes in cystic fibrosis 27
Long-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retrospective survey 25
Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study 21
A2A and Oxytocin receptor heteromers: exploring their role as modulators of glutamate release in adult striatal astrocytes 19
The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration 18
Dysmetabolism of Polyamines in a Transgenic Mouse Model Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Reactive Astrocytosis and Neuronal Suffering 15
Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation 13
Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization 9
Modulation of Plasmatic Matrix Metalloprotease 9: A Promising New Tool for Understanding the Variable Clinical Responses of Patients with Cystic Fibrosis to Cystic Fibrosis Transmembrane Conductance Regulator Modulators 7
OTR-D2 heterodimerization in striatal astrocytes: biochemical and biophysical evidence 5
Temperature-Dependent Olive Pomace Extraction for Obtaining Bioactive Compounds Preventing the Death of Murine Cortical Neurons 5
Totale 7.117
Categoria #
all - tutte 18.282
article - articoli 12.953
book - libri 370
conference - conferenze 4.532
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 427
Totale 36.564

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019411 0 0 0 0 0 0 0 0 5 78 173 155
2019/20202.025 105 58 107 141 190 205 272 142 169 315 248 73
2020/2021526 31 48 41 51 34 37 21 53 38 88 39 45
2021/2022951 30 55 82 71 39 58 63 219 48 98 41 147
2022/20231.023 74 70 15 118 109 148 6 99 180 21 155 28
2023/2024507 36 66 31 98 70 148 30 26 2 0 0 0
Totale 7.117