Among the different methods used to increase the aqueous drug solubility, the preparation of a solid dispersion with a soluble carrier represents an interesting formulative approach. We substituted polyvinylalcohol with triethyleneglycolmonoethylether and obtained a suitable material for the formulation of a solid dispersion of progesterone, by spray-drying. In particular, we evaluated the influence of the polyvinylalcohol substitution degree and the polymer-drug weight ratios in the preparative mixture on the progesterone dissolution rate in the aqueous environment. Copyright © 2002 Elsevier Science B.V.
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Titolo: | Polyvinylalcohol substituted with triethyleneglycolmonoethylether as a new material for preparation of solid dispersions of hydrophobic drugs |
Autori: | |
Data di pubblicazione: | 2002 |
Rivista: | |
Handle: | http://hdl.handle.net/11567/958616 |
Appare nelle tipologie: | 01.01 - Articolo su rivista |