Purpose: Patients with acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO) usually present very low respiratory system compliance (Cstrs) values (i.e., severe restrictive respiratory syndrome patients). As a consequence, they are at high risk of experiencing poor patient-ventilator interaction during assisted breathing. We hypothesized that monitoring of diaphragm electrical activity (EAdi) may enhance asynchrony assessment and that neurally adjusted ventilatory assist (NAVA) may reduce asynchrony, especially in more severely restricted patients. Methods: We enrolled ten consecutive ARDS patients with very low Cstrsvalues undergoing ECMO after switching from controlled to pressure support ventilation (PSV). We randomly tested (30 min) while recording EAdi: (1) PSV30 (PSV with an expiratory trigger at 30 % of flow peak value); (2) PSV1 (PSV with expiratory trigger at 1 %); (3) NAVA. During each step, we measured the EAdi-based asynchrony index (AIEAdi) = flow-, pressure- and EAdi-based asynchrony events/EAdi-based respiratory rate Ã 100. Results: AIEAdiwas high during all ventilation modes, and the most represented asynchrony pattern was specific for this population (i.e., premature cycling). NAVA was associated with significantly decreased, although suboptimal, AIEAdivalues in comparison to PSV30 and PSV1 (p < 0.01 for both). The PSV30-NAVA and PSV1-NAVA differences in AIEAdivalues were inversely correlated with patients' Cstrs(R2= 0.545, p = 0.01 and R2= 0.425, p < 0.05; respectively). Conclusions: EAdi allows accurate analysis of asynchrony patterns and magnitude in ARDS patients with very low Cstrsundergoing ECMO. In these patients, NAVA is associated with reduced asynchrony. Â© 2012 Springer-Verlag Berlin Heidelberg and ESICM.
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