An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.
Titolo: | Exploitation of the Ugi 5-centre-4-component reaction (U-5C-4CR) for the generation of diverse libraries of polycyclic (spiro)compounds | |
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Data di pubblicazione: | 2018 | |
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Handle: | http://hdl.handle.net/11567/923058 | |
Appare nelle tipologie: | 01.01 - Articolo su rivista |
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