An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.

Exploitation of the Ugi 5-centre-4-component reaction (U-5C-4CR) for the generation of diverse libraries of polycyclic (spiro)compounds

Lisa Moni;Fabio De Moliner;Silvia Garbarino;Andrea Basso
2018

Abstract

An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/923058
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