Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity

Many data highlight the benefits of the Mediterranean diet and its main lipid component, extra-virgin olive oil (EVOO). EVOO contains many phenolic compounds that have been found effective against several aging- and lifestyle-related diseases, including neurodegeneration. Oleuropein, a phenolic secoiroid glycoside, is the main polyphenol in the olive oil. It has been reported that the aglycone form of Oleuropein (OleA) interferes in vitro and in vivo with amyloid aggregation of a number of proteins/peptides involved in amyloid, particularly neurodegenerative, diseases avoiding the growth of toxic oligomers and displaying protection against cognitive deterioration.

Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity / Leri, Manuela; Oropesa-Nuñez, Reiner; Canale, Claudio; Raimondi, Sara; Giorgetti, Sofia; Bruzzone, Elena; Bellotti, Vittorio; Stefani, Massimo; Bucciantini, Monica. - STAMPA. - (2018), pp. 1-22.

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Titolo: Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity
Autori: 
CANALE, CLAUDIO
mostra contributor esterni 
Data di pubblicazione: 2018
Rivista: 
BIOCHIMICA ET BIOPHYSICA ACTA  
Citazione: Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity / Leri, Manuela; Oropesa-Nuñez, Reiner; Canale, Claudio; Raimondi, Sara; Giorgetti, Sofia; Bruzzone, Elena; Bellotti, Vittorio; Stefani, Massimo; Bucciantini, Monica. - STAMPA. - (2018), pp. 1-22.
Abstract: Many data highlight the benefits of the Mediterranean diet and its main lipid component, extra-virgin olive oil (EVOO). EVOO contains many phenolic compounds that have been found effective against several aging- and lifestyle-related diseases, including neurodegeneration. Oleuropein, a phenolic secoiroid glycoside, is the main polyphenol in the olive oil. It has been reported that the aglycone form of Oleuropein (OleA) interferes in vitro and in vivo with amyloid aggregation of a number of proteins/peptides involved in amyloid, particularly neurodegenerative, diseases avoiding the growth of toxic oligomers and displaying protection against cognitive deterioration.
Handle: http://hdl.handle.net/11567/898669
Appare nelle tipologie:01.01 - Articolo su rivista

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