Studies evidenced the relationship between adverse childhood experiences (ACEs) and tobacco smokingin adulthood. An appropriate parenting style has been found to be associated with children’s less fre-quent tobacco consumption. Hypothalamus-pituitary-adrenal (HPA) axis hyperactivity could representthe potential link between ACEs, mood disorders and smoking susceptibility. We studied a sample of 50male smokers, affected by nicotine dependence and 50 controls who never smoked. Self-reported ret-rospective perception of neglect (Child Experience of Care and Abuse: CECA-Q questionnaire), age ofsmoking onset, number of cigarette/day, psychiatric symptoms (Symptoms Check List 90 scale: SCL 90)and basal level of ACTH and cortisol have been evaluated. Total SCL-90 scores, CECA-Q values and cortisolplasma level were significantly higher among smokers. Cortisol and ACTH values showed a significantdirect correlation with CECA-Q and SCL90 total score and an inverse significant correlation with the ageof smoking. Cortisol and ACTH did not correlate with the number of cigarette smoked. Once controlledfor SCL90 and CECA-Q with multiple regression measures, the association between smoking and hor-mone levels reversed, suggesting that increased cortisol and ACTH basal levels were attributable topreexisting conditions such as early-life exposure to emotional neglect, psychological problems and apredisposition to addictive behavior plasma levelweresignificantly higheramongsmokers.CortisolandACTHvaluesshowedasignificant direct correlationwithCECA-QandSCL90totalscoreandaninversesignificant correlationwiththeage of smoking.CortisolandACTHdidnotcorrelatewiththenumberofcigarettesmoked.Oncecontrolled for SCL90andCECA-Qwithmultipleregressionmeasures,theassociationbetweensmokingandhor- mone levelsreversed,suggestingthatincreasedcortisolandACTHbasallevelswereattributableto preexistingconditionssuchasearly-lifeexposuretoemotionalneglect,psychologicalproblemsanda predisposition toaddictivebehavior

Perceived parental care during childhood, ACTH, cortisol and nicotine dependence in the adult.

MILANO, GIULIA;
2016

Abstract

Studies evidenced the relationship between adverse childhood experiences (ACEs) and tobacco smokingin adulthood. An appropriate parenting style has been found to be associated with children’s less fre-quent tobacco consumption. Hypothalamus-pituitary-adrenal (HPA) axis hyperactivity could representthe potential link between ACEs, mood disorders and smoking susceptibility. We studied a sample of 50male smokers, affected by nicotine dependence and 50 controls who never smoked. Self-reported ret-rospective perception of neglect (Child Experience of Care and Abuse: CECA-Q questionnaire), age ofsmoking onset, number of cigarette/day, psychiatric symptoms (Symptoms Check List 90 scale: SCL 90)and basal level of ACTH and cortisol have been evaluated. Total SCL-90 scores, CECA-Q values and cortisolplasma level were significantly higher among smokers. Cortisol and ACTH values showed a significantdirect correlation with CECA-Q and SCL90 total score and an inverse significant correlation with the ageof smoking. Cortisol and ACTH did not correlate with the number of cigarette smoked. Once controlledfor SCL90 and CECA-Q with multiple regression measures, the association between smoking and hor-mone levels reversed, suggesting that increased cortisol and ACTH basal levels were attributable topreexisting conditions such as early-life exposure to emotional neglect, psychological problems and apredisposition to addictive behavior plasma levelweresignificantly higheramongsmokers.CortisolandACTHvaluesshowedasignificant direct correlationwithCECA-QandSCL90totalscoreandaninversesignificant correlationwiththeage of smoking.CortisolandACTHdidnotcorrelatewiththenumberofcigarettesmoked.Oncecontrolled for SCL90andCECA-Qwithmultipleregressionmeasures,theassociationbetweensmokingandhor- mone levelsreversed,suggestingthatincreasedcortisolandACTHbasallevelswereattributableto preexistingconditionssuchasearly-lifeexposuretoemotionalneglect,psychologicalproblemsanda predisposition toaddictivebehavior
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11567/896947
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