The nucleus is the cellular organelle that harbors the genetic information into DNA, which forms with histone proteins the fundamental unit of chromatin. Chromatin is organized by physical and molecular forces, like phase separation and molecular crowding, into functional domains whose formation and mobility correlate to chromatin compaction influencing the genome outcome through gene expression regulation [1]. For these reasons, it is important to study chromatin compactness from both a spatial and a dynamic point of view.
Probing Chromatin Organization by Sorting of Short Sequence Fluorescence Correlation Spectroscopy
Di Bona, Melody;Pelicci, Simone;Vicidomini, Giuseppe;Diaspro, Alberto;
2018-01-01
Abstract
The nucleus is the cellular organelle that harbors the genetic information into DNA, which forms with histone proteins the fundamental unit of chromatin. Chromatin is organized by physical and molecular forces, like phase separation and molecular crowding, into functional domains whose formation and mobility correlate to chromatin compaction influencing the genome outcome through gene expression regulation [1]. For these reasons, it is important to study chromatin compactness from both a spatial and a dynamic point of view.
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