Chiral, enantiopure 1,3-amino alcohols, obtained through an organocatalytic Mannich reaction, have been used as starting materials for a concise sequence involving a diastereoselective Ugi reaction followed by various types of SN2 cyclization. In this way, different enantiopure heterocycles have been prepared, with both scaffold and decoration diversity (up to four diversity inputs).

Diversity-Oriented Synthesis of Various Enantiopure Heterocycles by Coupling Organocatalysis with Multicomponent Reactions

Caputo, Samantha;Banfi, Luca;Basso, Andrea;Galatini, Andrea;Moni, Lisa;Riva, Renata;Lambruschini, Chiara
2017

Abstract

Chiral, enantiopure 1,3-amino alcohols, obtained through an organocatalytic Mannich reaction, have been used as starting materials for a concise sequence involving a diastereoselective Ugi reaction followed by various types of SN2 cyclization. In this way, different enantiopure heterocycles have been prepared, with both scaffold and decoration diversity (up to four diversity inputs).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/887533
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