Moorfield regression analysis versus retinal nerve fiber layer in glaucoma and ocular hypertension

Purpose: To evaluate the agreement between Moorfield Regression Analysis (MRA) and peripapillary retinal nerve fibers layer thickness. Methods: 54 eyes with normal VF and 18 with early VF damage were classified as ocular hypertension or early primary open angle glaucoma (POAG) and were included in the study: All the subjects performed achromatic 30° visual field (VF) by Octopus Program G1X dynamic strategy and were imaged by HRT 3 and I-Vue OCT. Sectorial and global MRA and OCT parameters were used for the analysis. Kappa statistic was used to assess the agreement between methods. Results: A significant agreement between I-Vue OCT and MRA a good agreement was shown in the supero-nasal (κ 0.656) and nasal (κ 0.627) quadrants followed by the supero-temporal (κ 0.602) and inferotemporal (κ 0.586) sectors in all the eyes studied. Conclusion: Our results suggest that the measurements of the ganglion cells by HRT 3 and I-Vue OCT are not interchangeable.