20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

Pan, H; Gray, R; Braybrooke, J; Davies, C; Taylor, C; Mcgale, P; Peto, R; Pritchard, Ki; Bergh, J; Dowsett, M; Hayes, Df; Albain, K; Anderson, S; Arriagada, R; Barlow, W; Bartlett, J; Bergsten‐nordström, E; Bliss, J; Boccardo, F; Bradley, R; Brain, E; Cameron, D; Clarke, M; Coates, A; Coleman, R; Correa, C; Costantino, J; Cuzick, J; Davidson, N; Dodwell, D; Di Leo, A; Ewertz, M; Forbes, J; Gelber, R; Gnant, M; Goldhirsch, A; Goodwin, P; Hill, C; Ingle, J; Jagsi, R; Janni, W; Loibl, S; Mackinnon, E; Martin, M; Mukai, H; Norton, L; Ohashi, Y; Paik, S; Perez, E; Piccart, M; Pierce, L; Poortmans, P; Raina, V; Ravdin, P; Regan, M; Robertson, J; Rutgers, E; Slamon, D; Sparano, J; Swain, S; Tutt, A; Viale, G; Von Minckwitz, G; Wang, X; Whelan, T; Wilcken, N; Winer, E; Wolmark, N; Wood, W; Zambetti, M; Alberro, Ja; Ballester, B; Deulofeu, P; Fábregas, R; Fraile, M; Gubern, Jm; Janer, J; Moral, A; De Pablo Jl,; Peñalva, G; Puig, P; Ramos, M; Rojo, R; Santesteban, P; Serra, C; Solà, M; Solarnau, L; 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doi:10.1056/NEJMoa1701830

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment.

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Titolo:	20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Autori:	Pan H Gray R Braybrooke J Davies C Taylor C Mcgale P Peto R Pritchard Ki Bergh J Dowsett M Hayes Df Albain K Anderson S Arriagada R Barlow W Bartlett J Bergsten‐nordström E Bliss J BOCCARDO, FRANCESCO Bradley R Brain E Cameron D Clarke M Coates A Coleman R Correa C Costantino J Cuzick J Davidson N Dodwell D Di Leo A Ewertz M Forbes J Gelber R Gnant M Goldhirsch A Goodwin P Hill C Ingle J Jagsi R Janni W Loibl S Mackinnon E Martin M Mukai H Norton L Ohashi Y Paik S Perez E Piccart M Pierce L Poortmans P Raina V Ravdin P Regan M Robertson J Rutgers E Slamon D Sparano J Swain S Tutt A VIALE, GIUSEPPE Von Minckwitz G Wang X Whelan T Wilcken N Winer E Wolmark N Wood W Zambetti M Alberro Ja Ballester B Deulofeu P Fábregas R Fraile M Gubern Jm Janer J Moral A De Pablo Jl Peñalva G Puig P Ramos M Rojo R Santesteban P Serra C Solà M Solarnau L Solsona J Veloso E Vidal S Abe O Abe R Enomoto K Kikuchi K Koyama H Masuda H Nomura Y Sakai K Sugimachi K Toi M Tominaga T Uchino J Yoshida M Haybittle Jl Leonard Cf Calais G Garaud P Collett V Delmestri A Sayer J Harvey Vj Holdaway Im Kay Rg Mason Bh Forbes Jf Balic M Bartsch R Fesl C Fitzal F Fohler H Greil R Jakesz R Marth C Mlineritsch B Pfeiler G Singer Cf Steger Gg Stöger H Canney P Yosef Hma Focan C Peek U Oates Gd Powell J Durand M Mauriac L Dolci S Larsimont D Nogaret Jm Philippson C Piccart Mj Masood Mb Parker D Price Jj Lindsay Ma Mackey J Hupperets Psgj Bates T Blamey Rw Chetty U Ellis Io Mallon E Morgan Dal Patnick J Pinder S Lohrisch C Nichol A Bramwell Vh Chen Be Gelmon K Goss Pe Levine Mn Parulekar W Pater Jl Shepherd Le Tu D Berry D Broadwater G Cirrincione C Muss H Weiss Rb Abu‐zahra Ht Portnoj Sm Bowden S Brookes C Dunn J Fernando I Lee M Poole C Rea D Spooner D Barrett‐lee Pj Mansel Re Monypenny Ij Gordon Nh Davis Hl Sestak I Lehingue Y Romestaing P Dubois Jb Delozier T Griffon B Mace Lesec’h J De La Lande B Mouret‐fourme E Mustacchi G Petruzelka L Pribylova O Owen Jr Harbeck N Jänicke F Meisner C Schmitt M Thomssen C Meier P Shan Y Shao Yf Zhao Db Chen Zm Howell A Swindell R Boddington C Burrett Ja Cutter D Duane F Evans V Gettins L Godwin J James S Kerr A Liu H Mannu G Mchugh T Morris P Read S WANG, YAO Wang Z Albano J De Oliveira Cf Gervásio H Gordilho J Ejlertsen B Jensen Mb Johansen H Mouridsen H Palshof T Gelman Rs Harris Jr Henderson C Shapiro Cl Christiansen P Mouridsen Ht Fehm T Trampisch Hj Dalesio O De Vries Ege Rodenhuis S Van Tinteren H Comis Rl Davidson Ne Robert N Sledge G Solin Lj Sparano Ja Tormey Dc Dixon Jm Forrest P Jack W Kunkler I Rossbach J Klijn Jgm Treurniet‐donker Ad Van Putten Wlj Rotmensz N Veronesi U Bartelink H Bijker N Bogaerts J Cardoso F Cufer T Julien Jp Van De Velde Cjh Cunningham Mp Brufsky Am Coleman Re Llombart Ha Huovinen R Joensuu H Costa A Bonadonna G Gianni L Valagussa P Goldstein Lj Bonneterre J Fargeot P Fumoleau P Kerbrat P Luporsi E Namer M Carrasco E Segui Ma Eiermann W Hilfrich J Jonat W Kaufmann M Kreienberg R Schumacher M Bastert G Rauschecker H Sauer R Sauerbrei W Schauer A Blohmer Ju Costa Sd Eidtmann H Gerber B Jackisch C De Schryver A Vakaet L Belfiglio M Nicolucci A Pellegrini F Pirozzoli Mc Sacco M Valentini M Mcardle Cs Smith Dc Stallard S Dent Dm Gudgeon Ca Hacking A Murray E Panieri E Werner Id Galligioni E Leone B Vallejo Ct Zwenger A Lopez M Erazo A Medina Jy Horiguchi J Takei H Fentiman Is Hayward Jl Rubens Rd Skilton D Scheurlen H Sohn Hc Untch M Dafni U Markopoulos C Fountzilas G Mavroudis D Klefstrom P Blomqvist C Saarto T Gallen M Tinterri C Margreiter R De Lafontan B Mihura J Roché H Asselain B Salmon Rj Vilcoq Jr André F Delaloge S Koscielny S Michiels S RUBINO, COSIMO A'hern R Ellis P Kilburn L Yarnold Jr Benraadt J Kooi M Van De Velde Ao Van Dongen Ja Vermorken Jb Castiglione M Colleoni M Collins J Gelber Rd Lindtner J Price Kn Regan Mm Rudenstam Cm Senn Hj Thuerlimann B Bliss Jm Chilvers Ced Coombes Rc Hall E Marty M Buyse M Possinger K Schmid P Wallwiener D Bighin C BRUZZI, PAOLO DEL MASTRO, LUCIA Dozin B Pastorino S Pronzato P SERTOLI, MARIO ROBERTO Foster L George Wd Stewart Hj Stroner P Borovik R Hayat H Inbar Mj Peretz T Robinson E Camerini T Formelli F Martelli G Di Mauro Mg Perrone F Amadori D Martoni A Pannuti F Camisa R Musolino A Passalacqua R Iwata H Shien T Ikeda T Inokuchi K Sawa K Sonoo H Sadoon M Tulusan Ah Kohno N Miyashita M Takao S Ahn Jh Jung Kh Korzeniowski S Skolyszewski J Ogawa M Yamashita J Bastiaannet E Liefers Gj Christiaens R Neven P Paridaens R Van Den Bogaert W Braun S Martin P Romain S Janauer M Seifert M Sevelda P Zielinski Cc Hakes T Hudis Ca Wittes R Giokas G Kondylis D Lissaios B De La Huerta R Sainz Mg Ro J Camphausen K Danforth D Lichter A Lippman M Smart D Steinberg S D’amico C Lioce M Paradiso A Ohno S Bass G Brown A Bryant J Dignam J Fisher B Geyer C Mamounas Ep Redmond C Wickerham L Aihara T Hozumi Y Baum M Jackson Im Palmer Mk Ingle Jn Suman Vj Bengtsson No Emdin S Jonsson H Venturini M Lythgoe Jp Kissin M Erikstein B Hannisdal E Jacobsen Ab Reinertsen Kv Varhaug Je Gundersen S Hauer‐jensen M Høst H Nissen‐meyer R Mitchell Ak Robertson Jfr Ueo H Di Palma M Mathé G Misset Jl Levine M Morimoto K Takatsuka Y Crossley E Harris A Talbot D Taylor M Cocconi G Di Blasio B Ivanov V Paltuev R Semiglazov V Brockschmidt J Cooper Mr Falkson Ci Hadji P A’hern R Makris A Parton M Pennert K Powles Tj Smith Ie Gazet Jc Browne L Graham P Corcoran N Clack G Van Poznak C Deshpande N Di Martino L Douglas P Lindtner A Notter G Bryant Ajs Ewing Gh Firth La Krushen‐kosloski Jl Anderson H Killander F Malmström P Rydén L Arnesson Lg Carstensen J Dufmats M Fohlin H Nordenskjöld B Söderberg M Carpenter Jt Murray N Royle Gt Simmonds Pd Crowley J Gralow J Hortobagyi G Livingston R Martino S Osborne Ck Ravdin Pm Bondesson T Celebioglu F Dahlberg K Fornander T Fredriksson I Frisell J Göransson E Iiristo M Johansson U Lenner E Löfgren L Nikolaidis P Perbeck L Rotstein S Sandelin K Skoog L Svane G Af Trampe E Wadström C Maibach R Thürlimann B Holli K Rouhento K Safra T Brenner H Hercbergs A Yoshimoto M Paterson Ahg Fyles A Meakin Jw Panzarella T Bahi J Lemonnier J Martin Al Reid M Spittle M Bishop H Bundred Nj Forsyth S Pinder Se Deutsch Gp Kwong Dlw Pai Vr Senanayake F RUBAGOTTI, ALESSANDRA Hackshaw A Houghton J Ledermann J Monson K Tobias Js Carlomagno C De Laurentiis M De Placido S Williams L Bell R Hinsley S Marshall Hc Pierce Lj Solomayer E Horsman Jm Lester J Winter Mc Buzdar Au Hsu L Love Rr Ahlgren J Garmo H Holmberg L Liljegren G Lindman H Wärnberg F Asmar L Jones Se Aft R Gluz O Liedtke C Nitz U Litton A Wallgren A Karlsson P Linderholm Bk Chlebowski Rt Caffier H. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2017
Rivista:	NEW ENGLAND JOURNAL OF MEDICINE
Handle:	http://hdl.handle.net/11567/881777
Appare nelle tipologie:	01.01 - Articolo su rivista

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