20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

Pan, H; Gray, R; Braybrooke, J; Davies, C; Taylor, C; Mcgale, P; Peto, R; Pritchard, Ki; Bergh, J; Dowsett, M; Hayes, Df; Albain, K; Anderson, S; Arriagada, R; Barlow, W; Bartlett, J; Bergsten‐nordström, E; Bliss, J; Boccardo, F; Bradley, R; Brain, E; Cameron, D; Clarke, M; Coates, A; Coleman, R; Correa, C; Costantino, J; Cuzick, J; Davidson, N; Dodwell, D; Di Leo, A; Ewertz, M; Forbes, J; Gelber, R; Gnant, M; Goldhirsch, A; Goodwin, P; Hill, C; Ingle, J; Jagsi, R; Janni, W; Loibl, S; Mackinnon, E; Martin, M; Mukai, H; Norton, L; Ohashi, Y; Paik, S; Perez, E; Piccart, M; Pierce, L; Poortmans, P; Raina, V; Ravdin, P; Regan, M; Robertson, J; Rutgers, E; Slamon, D; Sparano, J; Swain, S; Tutt, A; Viale, G; Von Minckwitz, G; Wang, X; Whelan, T; Wilcken, N; Winer, E; Wolmark, N; Wood, W; Zambetti, M; Alberro, Ja; Ballester, B; Deulofeu, P; Fábregas, R; Fraile, M; Gubern, Jm; Janer, J; Moral, A; De Pablo Jl,; Peñalva, G; Puig, P; Ramos, M; Rojo, R; Santesteban, P; Serra, C; Solà, M; Solarnau, L; Solsona, J; Veloso, E; Vidal, S; Abe, O; Abe, R; Enomoto, K; Kikuchi, K; Koyama, H; Masuda, H; Nomura, Y; Sakai, K; Sugimachi, K; Toi, M; Tominaga, T; Uchino, J; Yoshida, M; Haybittle, Jl; Leonard, Cf; Calais, G; Garaud, P; Collett, V; Delmestri, A; Sayer, J; Harvey, Vj; Holdaway, Im; Kay, Rg; Mason, Bh; Forbes, Jf; Balic, M; Bartsch, R; Fesl, C; Fitzal, F; Fohler, H; Greil, R; Jakesz, R; Marth, C; Mlineritsch, B; Pfeiler, G; Singer, Cf; Steger, Gg; Stöger, H; Canney, P; Yosef, Hma; Focan, C; Peek, U; Oates, Gd; Powell, J; Durand, M; Mauriac, L; Dolci, S; Larsimont, D; Nogaret, Jm; Philippson, C; Piccart, Mj; Masood, Mb; Parker, D; Price, Jj; Lindsay, Ma; Mackey, J; Hupperets, Psgj; Bates, T; Blamey, Rw; Chetty, U; Ellis, Io; Mallon, E; Morgan, Dal; Patnick, J; Pinder, S; Lohrisch, C; Nichol, A; Bramwell, Vh; Chen, Be; Gelmon, K; Goss, Pe; Levine, Mn; Parulekar, W; Pater, Jl; Shepherd, Le; Tu, D; Berry, D; Broadwater, G; Cirrincione, C; Muss, H; Weiss, Rb; Abu‐zahra, Ht; Portnoj, Sm; Bowden, S; Brookes, C; Dunn, J; Fernando, I; Lee, M; Poole, C; Rea, D; Spooner, D; Barrett‐lee, Pj; Mansel, Re; Monypenny, Ij; Gordon, Nh; Davis, Hl; Sestak, I; Lehingue, Y; Romestaing, P; Dubois, Jb; Delozier, T; Griffon, B; Mace Lesec’h, J; De La Lande, B; Mouret‐fourme, E; Mustacchi, G; Petruzelka, L; Pribylova, O; Owen, Jr; Harbeck, N; Jänicke, F; Meisner, C; Schmitt, M; Thomssen, C; Meier, P; Shan, Y; Shao, Yf; Zhao, Db; Chen, Zm; Howell, A; Swindell, R; Boddington, C; Burrett, Ja; Cutter, D; Duane, F; Evans, V; Gettins, L; Godwin, J; James, S; Kerr, A; Liu, H; Mannu, G; Mchugh, T; Morris, P; Read, S; Wang, Y; Wang, Z; Albano, J; De Oliveira Cf,; Gervásio, H; Gordilho, J; Ejlertsen, B; Jensen, Mb; Johansen, H; Mouridsen, H; Palshof, T; Gelman, Rs; Harris, Jr; Henderson, C; Shapiro, Cl; Christiansen, P; Mouridsen, Ht; Fehm, T; Trampisch, Hj; Dalesio, O; De Vries Ege,; Rodenhuis, S; Van Tinteren, H; Comis, Rl; Davidson, Ne; Robert, N; Sledge, G; Solin, Lj; Sparano, Ja; Tormey, Dc; Dixon, Jm; Forrest, P; Jack, W; Kunkler, I; Rossbach, J; Klijn, Jgm; Treurniet‐donker, Ad; Van Putten Wlj,; Rotmensz, N; Veronesi, U; Bartelink, H; Bijker, N; Bogaerts, J; Cardoso, F; Cufer, T; Julien, Jp; Van De Velde Cjh,; Cunningham, Mp; Brufsky, Am; Coleman, Re; Llombart, Ha; Huovinen, R; Joensuu, H; Costa, A; Bonadonna, G; Gianni, L; Valagussa, P; Goldstein, Lj; Bonneterre, J; Fargeot, P; Fumoleau, P; Kerbrat, P; Luporsi, E; Namer, M; Carrasco, E; Segui, Ma; Eiermann, W; Hilfrich, J; Jonat, W; Kaufmann, M; Kreienberg, R; Schumacher, M; Bastert, G; Rauschecker, H; Sauer, R; Sauerbrei, W; Schauer, A; Blohmer, Ju; Costa, Sd; Eidtmann, H; Gerber, B; Jackisch, C; De Schryver, A; Vakaet, L; Belfiglio, M; Nicolucci, A; Pellegrini, F; Pirozzoli, Mc; Sacco, M; Valentini, M; Mcardle, Cs; Smith, Dc; Stallard, S; Dent, Dm; Gudgeon, Ca; Hacking, A; Murray, E; Panieri, E; Werner, Id; Galligioni, E; Leone, B; Vallejo, Ct; Zwenger, A; Lopez, M; Erazo, A; Medina, Jy; Horiguchi, J; Takei, H; Fentiman, Is; Hayward, Jl; Rubens, Rd; Skilton, D; Scheurlen, H; Sohn, Hc; Untch, M; Dafni, U; Markopoulos, C; Fountzilas, G; Mavroudis, D; Klefstrom, P; Blomqvist, C; Saarto, T; Gallen, M; Tinterri, C; Margreiter, R; De Lafontan, B; Mihura, J; Roché, H; Asselain, B; Salmon, Rj; Vilcoq, Jr; André, F; Delaloge, S; Koscielny, S; Michiels, S; Rubino, C; A'hern, R; Ellis, P; Kilburn, L; Yarnold, Jr; Benraadt, J; Kooi, M; Van De Velde Ao,; Van Dongen Ja,; Vermorken, Jb; Castiglione, M; Colleoni, M; Collins, J; Gelber, Rd; Lindtner, J; Price, Kn; Regan, Mm; Rudenstam, Cm; Senn, Hj; Thuerlimann, B; Bliss, Jm; Chilvers, Ced; Coombes, Rc; Hall, E; Marty, M; Buyse, M; Possinger, K; Schmid, P; Wallwiener, D; Bighin, C; Bruzzi, P; Del Mastro, L; Dozin, B; Pastorino, S; Pronzato, P; Sertoli, Mr; Foster, L; George, Wd; Stewart, Hj; Stroner, P; Borovik, R; Hayat, H; Inbar, Mj; Peretz, T; Robinson, E; Camerini, T; Formelli, F; Martelli, G; Di Mauro Mg,; Perrone, F; Amadori, D; Martoni, A; Pannuti, F; Camisa, R; Musolino, A; Passalacqua, R; Iwata, H; Shien, T; Ikeda, T; Inokuchi, K; Sawa, K; Sonoo, H; Sadoon, M; Tulusan, Ah; Kohno, N; Miyashita, M; Takao, S; Ahn, Jh; Jung, Kh; Korzeniowski, S; Skolyszewski, J; Ogawa, M; Yamashita, J; Bastiaannet, E; Liefers, Gj; Christiaens, R; Neven, P; Paridaens, R; Van Den Bogaert, W; Braun, S; Martin, P; Romain, S; Janauer, M; Seifert, M; Sevelda, P; Zielinski, Cc; Hakes, T; Hudis, Ca; Wittes, R; Giokas, G; Kondylis, D; Lissaios, B; De La Huerta, R; Sainz, Mg; Ro, J; Camphausen, K; Danforth, D; Lichter, A; Lippman, M; Smart, D; Steinberg, S; D’amico, C; Lioce, M; Paradiso, A; Ohno, S; Bass, G; Brown, A; Bryant, J; Dignam, J; Fisher, B; Geyer, C; Mamounas, Ep; Redmond, C; Wickerham, L; Aihara, T; Hozumi, Y; Baum, M; Jackson, Im; Palmer, Mk; Ingle, Jn; Suman, Vj; Bengtsson, No; Emdin, S; Jonsson, H; Venturini, M; Lythgoe, Jp; Kissin, M; Erikstein, B; Hannisdal, E; Jacobsen, Ab; Reinertsen, Kv; Varhaug, Je; Gundersen, S; Hauer‐jensen, M; Høst, H; Nissen‐meyer, R; Mitchell, Ak; Robertson, Jfr; Ueo, H; Di Palma, M; Mathé, G; Misset, Jl; Levine, M; Morimoto, K; Takatsuka, Y; Crossley, E; Harris, A; Talbot, D; Taylor, M; Cocconi, G; Di Blasio, B; Ivanov, V; Paltuev, R; Semiglazov, V; Brockschmidt, J; Cooper, Mr; Falkson, Ci; Hadji, P; A’hern, R; Makris, A; Parton, M; Pennert, K; Powles, Tj; Smith, Ie; Gazet, Jc; Browne, L; Graham, P; Corcoran, N; Clack, G; Van Poznak, C; Deshpande, N; Di Martino, L; Douglas, P; Lindtner, A; Notter, G; Bryant, Ajs; Ewing, Gh; Firth, La; Krushen‐kosloski, Jl; Anderson, H; Killander, F; Malmström, P; Rydén, L; Arnesson, Lg; Carstensen, J; Dufmats, M; Fohlin, H; Nordenskjöld, B; Söderberg, M; Carpenter, Jt; Murray, N; Royle, Gt; Simmonds, Pd; Crowley, J; Gralow, J; Hortobagyi, G; Livingston, R; Martino, S; Osborne, Ck; Ravdin, Pm; Bondesson, T; Celebioglu, F; Dahlberg, K; Fornander, T; Fredriksson, I; Frisell, J; Göransson, E; Iiristo, M; Johansson, U; Lenner, E; Löfgren, L; Nikolaidis, P; Perbeck, L; Rotstein, S; Sandelin, K; Skoog, L; Svane, G; Af Trampe, E; Wadström, C; Maibach, R; Thürlimann, B; Holli, K; Rouhento, K; Safra, T; Brenner, H; Hercbergs, A; Yoshimoto, M; Paterson, Ahg; Fyles, A; Meakin, Jw; Panzarella, T; Bahi, J; Lemonnier, J; Martin, Al; Reid, M; Spittle, M; Bishop, H; Bundred, Nj; Forsyth, S; Pinder, Se; Deutsch, Gp; Kwong, Dlw; Pai, Vr; Senanayake, F; Rubagotti, A; Hackshaw, A; Houghton, J; Ledermann, J; Monson, K; Tobias, Js; Carlomagno, C; De Laurentiis, M; De Placido, S; Williams, L; Bell, R; Hinsley, S; Marshall, Hc; Pierce, Lj; Solomayer, E; Horsman, Jm; Lester, J; Winter, Mc; Buzdar, Au; Hsu, L; Love, Rr; Ahlgren, J; Garmo, H; Holmberg, L; Liljegren, G; Lindman, H; Wärnberg, F; Asmar, L; Jones, Se; Aft, R; Gluz, O; Liedtke, C; Nitz, U; Litton, A; Wallgren, A; Karlsson, P; Linderholm, Bk; Chlebowski, Rt; Caffier, H.

doi:10.1056/NEJMoa1701830

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment.

Risorse UNIGE

Titolo:	20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Autori:	Pan H Gray R Braybrooke J Davies C Taylor C Mcgale P Peto R Pritchard Ki Bergh J Dowsett M Hayes Df Albain K Anderson S Arriagada R Barlow W Bartlett J Bergsten‐nordström E Bliss J BOCCARDO, FRANCESCO Bradley R Brain E Cameron D Clarke M Coates A Coleman R Correa C Costantino J Cuzick J Davidson N Dodwell D Di Leo A Ewertz M Forbes J Gelber R Gnant M Goldhirsch A Goodwin P Hill C Ingle J Jagsi R Janni W Loibl S Mackinnon E Martin M Mukai H Norton L Ohashi Y Paik S Perez E Piccart M Pierce L Poortmans P Raina V Ravdin P Regan M Robertson J Rutgers E Slamon D Sparano J Swain S Tutt A VIALE, GIUSEPPE Von Minckwitz G Wang X Whelan T Wilcken N Winer E Wolmark N Wood W Zambetti M Alberro Ja Ballester B Deulofeu P Fábregas R Fraile M Gubern Jm Janer J Moral A De Pablo Jl Peñalva G Puig P Ramos M Rojo R Santesteban P Serra C Solà M Solarnau L Solsona J Veloso E Vidal S Abe O Abe R Enomoto K Kikuchi K Koyama H Masuda H Nomura Y Sakai K Sugimachi K Toi M Tominaga T Uchino J Yoshida M Haybittle Jl Leonard Cf Calais G Garaud P Collett V Delmestri A Sayer J Harvey Vj Holdaway Im Kay Rg Mason Bh Forbes Jf Balic M Bartsch R Fesl C Fitzal F Fohler H Greil R Jakesz R Marth C Mlineritsch B Pfeiler G Singer Cf Steger Gg Stöger H Canney P Yosef Hma Focan C Peek U Oates Gd Powell J Durand M Mauriac L Dolci S Larsimont D Nogaret Jm Philippson C Piccart Mj Masood Mb Parker D Price Jj Lindsay Ma Mackey J Hupperets Psgj Bates T Blamey Rw Chetty U Ellis Io Mallon E Morgan Dal Patnick J Pinder S Lohrisch C Nichol A Bramwell Vh Chen Be Gelmon K Goss Pe Levine Mn Parulekar W Pater Jl Shepherd Le Tu D Berry D Broadwater G Cirrincione C Muss H Weiss Rb Abu‐zahra Ht Portnoj Sm Bowden S Brookes C Dunn J Fernando I Lee M Poole C Rea D Spooner D Barrett‐lee Pj Mansel Re Monypenny Ij Gordon Nh Davis Hl Sestak I Lehingue Y Romestaing P Dubois Jb Delozier T Griffon B Mace Lesec’h J De La Lande B Mouret‐fourme E Mustacchi G Petruzelka L Pribylova O Owen Jr Harbeck N Jänicke F Meisner C Schmitt M Thomssen C Meier P Shan Y Shao Yf Zhao Db Chen Zm Howell A Swindell R Boddington C Burrett Ja Cutter D Duane F Evans V Gettins L Godwin J James S Kerr A Liu H Mannu G Mchugh T Morris P Read S WANG, YAO Wang Z Albano J De Oliveira Cf Gervásio H Gordilho J Ejlertsen B Jensen Mb Johansen H Mouridsen H Palshof T Gelman Rs Harris Jr Henderson C Shapiro Cl Christiansen P Mouridsen Ht Fehm T Trampisch Hj Dalesio O De Vries Ege Rodenhuis S Van Tinteren H Comis Rl Davidson Ne Robert N Sledge G Solin Lj Sparano Ja Tormey Dc Dixon Jm Forrest P Jack W Kunkler I Rossbach J Klijn Jgm Treurniet‐donker Ad Van Putten Wlj Rotmensz N Veronesi U Bartelink H Bijker N Bogaerts J Cardoso F Cufer T Julien Jp Van De Velde Cjh Cunningham Mp Brufsky Am Coleman Re Llombart Ha Huovinen R Joensuu H Costa A Bonadonna G Gianni L Valagussa P Goldstein Lj Bonneterre J Fargeot P Fumoleau P Kerbrat P Luporsi E Namer M Carrasco E Segui Ma Eiermann W Hilfrich J Jonat W Kaufmann M Kreienberg R Schumacher M Bastert G Rauschecker H Sauer R Sauerbrei W Schauer A Blohmer Ju Costa Sd Eidtmann H Gerber B Jackisch C De Schryver A Vakaet L Belfiglio M Nicolucci A Pellegrini F Pirozzoli Mc Sacco M VALENTINI, MATTEO Mcardle Cs Smith Dc Stallard S Dent Dm Gudgeon Ca Hacking A Murray E Panieri E Werner Id Galligioni E Leone B Vallejo Ct Zwenger A Lopez M Erazo A Medina Jy Horiguchi J Takei H Fentiman Is Hayward Jl Rubens Rd Skilton D Scheurlen H Sohn Hc Untch M Dafni U Markopoulos C Fountzilas G Mavroudis D Klefstrom P Blomqvist C Saarto T Gallen M Tinterri C Margreiter R De Lafontan B Mihura J Roché H Asselain B Salmon Rj Vilcoq Jr André F Delaloge S Koscielny S Michiels S RUBINO, COSIMO A'hern R Ellis P Kilburn L Yarnold Jr Benraadt J Kooi M Van De Velde Ao Van Dongen Ja Vermorken Jb Castiglione M Colleoni M Collins J Gelber Rd Lindtner J Price Kn Regan Mm Rudenstam Cm Senn Hj Thuerlimann B Bliss Jm Chilvers Ced Coombes Rc Hall E Marty M Buyse M Possinger K Schmid P Wallwiener D Bighin C BRUZZI, PAOLO DEL MASTRO, LUCIA Dozin B Pastorino S Pronzato P SERTOLI, MARIO ROBERTO Foster L George Wd Stewart Hj Stroner P Borovik R Hayat H Inbar Mj Peretz T Robinson E Camerini T Formelli F Martelli G Di Mauro Mg Perrone F Amadori D Martoni A Pannuti F Camisa R Musolino A Passalacqua R Iwata H Shien T Ikeda T Inokuchi K Sawa K Sonoo H Sadoon M Tulusan Ah Kohno N Miyashita M Takao S Ahn Jh Jung Kh Korzeniowski S Skolyszewski J Ogawa M Yamashita J Bastiaannet E Liefers Gj Christiaens R Neven P Paridaens R Van Den Bogaert W Braun S Martin P Romain S Janauer M Seifert M Sevelda P Zielinski Cc Hakes T Hudis Ca Wittes R Giokas G Kondylis D Lissaios B De La Huerta R Sainz Mg Ro J Camphausen K Danforth D Lichter A Lippman M Smart D Steinberg S D’amico C Lioce M Paradiso A Ohno S Bass G Brown A Bryant J Dignam J Fisher B Geyer C Mamounas Ep Redmond C Wickerham L Aihara T Hozumi Y Baum M Jackson Im Palmer Mk Ingle Jn Suman Vj Bengtsson No Emdin S Jonsson H Venturini M Lythgoe Jp Kissin M Erikstein B Hannisdal E Jacobsen Ab Reinertsen Kv Varhaug Je Gundersen S Hauer‐jensen M Høst H Nissen‐meyer R Mitchell Ak Robertson Jfr Ueo H Di Palma M Mathé G Misset Jl Levine M Morimoto K Takatsuka Y Crossley E Harris A Talbot D Taylor M Cocconi G Di Blasio B Ivanov V Paltuev R Semiglazov V Brockschmidt J Cooper Mr Falkson Ci Hadji P A’hern R Makris A Parton M Pennert K Powles Tj Smith Ie Gazet Jc Browne L Graham P Corcoran N Clack G Van Poznak C Deshpande N Di Martino L Douglas P Lindtner A Notter G Bryant Ajs Ewing Gh Firth La Krushen‐kosloski Jl Anderson H Killander F Malmström P Rydén L Arnesson Lg Carstensen J Dufmats M Fohlin H Nordenskjöld B Söderberg M Carpenter Jt Murray N Royle Gt Simmonds Pd Crowley J Gralow J Hortobagyi G Livingston R Martino S Osborne Ck Ravdin Pm Bondesson T Celebioglu F Dahlberg K Fornander T Fredriksson I Frisell J Göransson E Iiristo M Johansson U Lenner E Löfgren L Nikolaidis P Perbeck L Rotstein S Sandelin K Skoog L Svane G Af Trampe E Wadström C Maibach R Thürlimann B Holli K Rouhento K Safra T Brenner H Hercbergs A Yoshimoto M Paterson Ahg Fyles A Meakin Jw Panzarella T Bahi J Lemonnier J Martin Al Reid M Spittle M Bishop H Bundred Nj Forsyth S Pinder Se Deutsch Gp Kwong Dlw Pai Vr Senanayake F RUBAGOTTI, ALESSANDRA Hackshaw A Houghton J Ledermann J Monson K Tobias Js Carlomagno C De Laurentiis M De Placido S Williams L Bell R Hinsley S Marshall Hc Pierce Lj Solomayer E Horsman Jm Lester J Winter Mc Buzdar Au Hsu L Love Rr Ahlgren J Garmo H Holmberg L Liljegren G Lindman H Wärnberg F Asmar L Jones Se Aft R Gluz O Liedtke C Nitz U Litton A Wallgren A Karlsson P Linderholm Bk Chlebowski Rt Caffier H. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2017
Rivista:	NEW ENGLAND JOURNAL OF MEDICINE
Handle:	http://hdl.handle.net/11567/881777
Appare nelle tipologie:	01.01 - Articolo su rivista

File in questo prodotto:

File	Descrizione	Tipologia
emss-75008.pdf		Documento in versione editoriale	Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11567/881777

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CINECA IRIS Institutional Research Information System

File in questo prodotto: