Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis

Puthenparampil, Marco; Federle, Lisa; Poggiali, Davide; Miante, Silvia; Signori, Alessio; Pilotto, Elisabetta; Rinaldi, Francesca; Perini, Paola; Sormani, Maria Pia; Midena, Edoardo; Gallo, Paolo

doi:10.1371/journal.pone.0183957

Increasing evidence suggest that neuronal damage is an early and diffuse feature of Multiple Sclerosis (MS) pathology. Analysis of the optic pathway may help to clarify the mechanisms involved in grey matter damage in MS. Purpose of our study was to investigate the relationship between inflammation and neurodegeneration and to achieve evidence of trans-synaptic degeneration in the optic pathway in MS at clinical onset.

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Titolo:	Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis
Autori:	Puthenparampil, Marco Federle, Lisa Poggiali, Davide Miante, Silvia SIGNORI, ALESSIO Pilotto, Elisabetta Rinaldi, Francesca Perini, Paola SORMANI, MARIA PIA Midena, Edoardo Gallo, Paolo mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2017
Rivista:	PLOS ONE
Handle:	http://hdl.handle.net/11567/876066
Appare nelle tipologie:	01.01 - Articolo su rivista

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http://hdl.handle.net/11567/876066

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