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EnglishBackground: Stereoelectroencephalography (SEEG) methodology, originally developed by Talairach and Bancaud, is progressively gaining popularity for the presurgical invasive evaluation of drug-resistant epilepsies. Objective: To describe recent SEEG methodological implementations carried out in our center, to evaluate safety, and to analyze in vivo application accuracy in a consecutive series of 500 procedures with a total of 6496 implanted electrodes. Methods: Four hundred nineteen procedures were performed with the traditional 2-step surgical workflow, which was modified for the subsequent 81 procedures. The new workflow entailed acquisition of brain 3-dimensional angiography and magnetic resonance imaging in frameless and markerless conditions, advanced multimodal planning, and robot-assisted implantation. Quantitative analysis for in vivo entry point and target point localization error was performed on a sub-data set of 118 procedures (1567 electrodes). Results: The methodology allowed successful implantation in all cases. Major complication rate was 12 of 500 (2.4%), including 1 death for indirect morbidity. Median entry point localization error was 1.43 mm (interquartile range, 0.91-2.21 mm) with the traditional workflow and 0.78 mm (interquartile range, 0.49-1.08 mm) with the new one (P < 2.2 × 10). Median target point localization errors were 2.69 mm (interquartile range, 1.89-3.67 mm) and 1.77 mm (interquartile range, 1.25-2.51 mm; P < 2.2 × 10), respectively. Conclusion: SEEG is a safe and accurate procedure for the invasive assessment of the epileptogenic zone. Traditional Talairach methodology, implemented by multimodal planning and robot-assisted surgery, allows direct electrical recording from superficial and deep-seated brain structures, providing essential information in the most complex cases of drug-resistant epilepsy. Abbreviations: DSA, digital subtraction angiographyEP, entry pointEPLE, entry point localization errorEZ, epileptogenic zoneSEEG, stereoelectroencephalographyTP, target pointTPLE, target point localization error. Copyright © 2012 by the Congress of Neurological Surgeons.
Stereoelectroencephalography: Surgical methodology, safety, and stereotactic application accuracy in 500 procedures / Cardinale, Francesco; Cossu, Massimo; Castana, Laura; Casaceli, Giuseppe; Schiariti, Marco Paolo; Miserocchi, Anna; Fuschillo, Dalila; Moscato, Alessio; Caborni, Chiara; Arnulfo, Gabriele; Lo Russo, Giorgio. - In: NEUROSURGERY. - ISSN 0148-396X. - ELETTRONICO. - 72(2013), pp. 353-366.
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| Titolo: | Stereoelectroencephalography: Surgical methodology, safety, and stereotactic application accuracy in 500 procedures |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Citazione: | Stereoelectroencephalography: Surgical methodology, safety, and stereotactic application accuracy in 500 procedures / Cardinale, Francesco; Cossu, Massimo; Castana, Laura; Casaceli, Giuseppe; Schiariti, Marco Paolo; Miserocchi, Anna; Fuschillo, Dalila; Moscato, Alessio; Caborni, Chiara; Arnulfo, Gabriele; Lo Russo, Giorgio. - In: NEUROSURGERY. - ISSN 0148-396X. - ELETTRONICO. - 72(2013), pp. 353-366. |
| Handle: | http://hdl.handle.net/11567/868943 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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