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Adaptive Reuse of Religious and Sacred Heritage: Preserving Material Traces and Spirit of Place

The theme of adaptive reuse, of great topicality for those who deal with built heritage, has its roots in the recent past, dating back to the end of the last century, when the problem of reuse proved to be competitive, for economic and cultural reasons, with respect to total demolition and reconstruction. Since then, various disciplinary and methodological approaches have been confronted with theories and methods of intervention, on an ever-expanding Cultural Heritage. The article offers a re...

Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells

The airway epithelium contains ionocytes, a rare cell type with high expression of Forkhead Box I1 (FOXI1) transcription factor and Cystic Fibrosis Transmembrane conductance Regulator (CFTR), a chloride channel that is defective in cystic fibrosis (CF). Our aim was to verify if ionocyte development is altered in CF and to investigate the relationship between ionocytes and CFTR-dependent chloride secretion. We collected nasal cells by brushing to determine ionocyte abundance. Nasal and bronchi...

New antibiotics for the treatment of nonfermenting Gram-negative bacteria

Purpose of review To discuss the current literature on novel agents for the treatment of carbapenem-resistant nonfermenting Gram-negative bacteria (NF-GNB) infections. Recent findings Some novel agents have recently become available that are expected to replace classical polymyxins as the first-line options for the treatment of carbapenem-resistant NF-GNB infections. In this narrative review, we provide a brief overview of the differential activity of various recently approved agents against ...

Endometriosis and Infertility: Prognostic Value of #Enzian Classification Compared to rASRM and EFI Score

This study's objective was to compare the predictive validity of the three most utilized classification scores for endometriosis, #Enzian, EFI, and rASRM, in achieving a spontaneous pregnancy or pregnancy via assisted reproductive technology (ART) after surgery for endometriosis. The monocentric retrospective study was carried out from January 2012 to December 2021 at the gynaecology department of the cantonal hospital of Fribourg. Patients consulting for infertility and operated on for endom...

Emotional and social functioning after stroke in childhood: a systematic review

PurposeTo provide an overview of the effects of pediatric stroke on emotional and social functioning in childhood.MethodsA literature review was completed in accordance with the Preferred Reporting Items for Systematic Reviews. A systematic search of studies on internalizing problems and social functioning after pediatric stroke in PsycInfo, PsycArticles, and PubMed databases was conducted from inception to November 2021. A total of 583 studies were identified, and 32 met the inclusion criter...

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