A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine. © 2014 Elsevier Ltd. All rights reserved.
Clofazimine analogs with antileishmanial and antiplasmodial activity
TONELLI, MICHELE;BOIDO, VITO;SPARATORE, FABIO;
2015-01-01
Abstract
A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine. © 2014 Elsevier Ltd. All rights reserved.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Clofaz antileishmania.pdf
accesso chiuso
Descrizione: Clofazimina antileishmania.pdf
Tipologia:
Documento in versione editoriale
Dimensione
868.34 kB
Formato
Adobe PDF
|
868.34 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
