CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishSalicylaldehydes and protected 1,2-amino alcohols have been convergently converted into a series of 2,3-dihydrobenzo[ f][1,4]oxazepines, which undergo an Ugi–Joullié multicomponent reaction with unusual long-range diastereoselectivity. This protocol allows the diastereoselective preparation, in only two steps, of a series of drug-like tetrahydrobenzo[ f][1,4]oxazepines, with the combinatorial introduction of four diversity points. The possibility of obtaining these compounds in enantiomerically pure form was also demonstrated.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Long-range Diastereoselection in an Ugi Reaction: Stereocontrolled and Diversity Oriented Synthesis of Tetrahydrobenzoxazepines |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Abstract: | Salicylaldehydes and protected 1,2-amino alcohols have been convergently converted into a series of 2,3-dihydrobenzo[ f][1,4]oxazepines, which undergo an Ugi–Joullié multicomponent reaction with unusual long-range diastereoselectivity. This protocol allows the diastereoselective preparation, in only two steps, of a series of drug-like tetrahydrobenzo[ f][1,4]oxazepines, with the combinatorial introduction of four diversity points. The possibility of obtaining these compounds in enantiomerically pure form was also demonstrated. |
| Handle: | http://hdl.handle.net/11567/631177 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
File in questo prodotto:
http://hdl.handle.net/11567/631177
Copyright © 2019