The past 15 years have witnessed an enormous effort in studying Bcell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease. This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the Bcell receptor (BcR) of the leukemic clones. These stud ies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/ expansion and underscore the informative value represented by BcR analyses.
Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?
FAIS, FRANCO;BRUNO, SILVIA;GHIOTTO, FABIO GIUSEPPE
2010-01-01
Abstract
The past 15 years have witnessed an enormous effort in studying Bcell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease. This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the Bcell receptor (BcR) of the leukemic clones. These stud ies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/ expansion and underscore the informative value represented by BcR analyses.
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