Objective. Nonsebaceous lymphadenomas are rare, benign neoplasms. We emphasize the role of immunohistochemistry and attempt to elucidate the pathogenesis, investigating the distribution of two transcription factors, MYC and BLIMP1. Study Design. A 70-year-old man was evaluated for a 3 cm, left parotid mass. Ultrasound-guided fineneedle aspiration biopsy findings were suggestive of a diagnosis of pleomorphic adenoma. A left superficial parotidectomy was performed and based on histopathology a diagnosis of lymphadenoma, nonsebaceous type, was rendered. Results. The tumor was positive for AE1/3, CKA, Bcl2, P63, CD79a, CD3 and MYC; focal positive for CK7 and EMA; negative for CD10, Calponin, CD117 and BLIMP1. Conclusions. The rarity and its superficial resemblance to commoner salivary-gland tumors may present a diagnostic challenge for pathologists. The expression of MYC in the ductal component and the differentiation-related expression of PRDM1 in the superficial keratinizing layers, point to a role for these two transcription factors in the pathogenesis of this neoplasm.
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|Titolo:||Nonsebaceous lymphadenoma of salivary gland: report of a case with immunohistochemistry and review of the literature|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||01.01 - Articolo su rivista|