Plasmaaldosterone concentration has been measured by radioimmunoassay in a tortoise species TestudohermanniGmelin. Control levels were very low, 8.26 ± 0.2 ng/100 ml, if compared with the determination carried out in other reptilian species with the same RIA method. A sodium-loaded diet for a prolonged period (30 days) depressed aldosteronelevels but administration of a diuretic produced a significant elevation. Plasmaaldosterone, sodium, and potassium concentrations were significantly correlated. Administration of a mammalian inhibitor of aldosterone (spironolactone) was not followed by a significant plasmaaldosterone or electrolyte changes. These data are consistent in supporting the hypothesis that aldosterone is involved in hydromineral regulation, at least in terrestrial chelonians, with a direct action on the renal proximal tubule.
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