Amyloid-like fibrils have been obtained upon incubation of a diluted aqueous solution of cytochrome c at neutral pH in the presence of gold nanoparticles. The interaction of the cytochrome c suspension, containing proteins in both the monomeric and fibrillar state, with the freshly cleaved highly ordered pyrolytic graphite (HOPG) surface results in a double process. First, it leads to a nanopatterning of the HOPG surface and, second, it promotes the self-aligning of cytochrome c protofilaments on the nanopatterned HOPG surface.
Aligning Amyloid-Like Fibrils on Nanopatterned Graphite
PENCO, AMANDA;CANEPA, MAURIZIO;ROLANDI, RANIERI;CAVALLERI, ORNELLA
2012-01-01
Abstract
Amyloid-like fibrils have been obtained upon incubation of a diluted aqueous solution of cytochrome c at neutral pH in the presence of gold nanoparticles. The interaction of the cytochrome c suspension, containing proteins in both the monomeric and fibrillar state, with the freshly cleaved highly ordered pyrolytic graphite (HOPG) surface results in a double process. First, it leads to a nanopatterning of the HOPG surface and, second, it promotes the self-aligning of cytochrome c protofilaments on the nanopatterned HOPG surface.
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