An efficient and convergent Ugi synthesis of enantiomerically pure N-acyl-2,5-disubstituted pyrrolidines was coupled with an appropriate secondary transformation to give two series of bicyclic derivatives, namely hexahydro pyrrolo-oxazocinediones and -diazepinediones.
A convergent synthesis of enantiopure bicyclic scaffolds through multicomponent Ugi reaction
BANFI, LUCA;BASSO, ANDREA;GUANTI, GIUSEPPE;RIVA, RENATA
2008-01-01
Abstract
An efficient and convergent Ugi synthesis of enantiomerically pure N-acyl-2,5-disubstituted pyrrolidines was coupled with an appropriate secondary transformation to give two series of bicyclic derivatives, namely hexahydro pyrrolo-oxazocinediones and -diazepinediones.
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