A phytochemical study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant platelet antiaggregatingactivity. The known compounds isopimaric acid (2), 14-alpha-hydroxy-isopimaric acid (3), 3 beta-hydroxy-isopimaric acid (4), 7,8 beta-dihydrosalviacoccin (5), betulinic acid (6), and ursolic acid (7) were isolated together with the new diterpene 1. The structure of 1 was determined as 15,16-epoxy-cleroda-3-en-7 alpha,10 beta-dihydroxy-12,17;19,18-diolide on the basis of spectroscopic data analysis. Among all tested compounds, 2 showed a significant concentration-dependent antiaggregating activity when ADP (3 mu M) was used as agonist on rat platelets. Conversely, 1 increased ADP-induced plateletaggregation.
Platelet Antiaggregating Activity and Chemical Constituents of Salvia x jamensis J. Compton
BISIO, ANGELA;ROMUSSI, GIOVANNI;RUSSO, ELEONORA;
2008-01-01
Abstract
A phytochemical study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant platelet antiaggregatingactivity. The known compounds isopimaric acid (2), 14-alpha-hydroxy-isopimaric acid (3), 3 beta-hydroxy-isopimaric acid (4), 7,8 beta-dihydrosalviacoccin (5), betulinic acid (6), and ursolic acid (7) were isolated together with the new diterpene 1. The structure of 1 was determined as 15,16-epoxy-cleroda-3-en-7 alpha,10 beta-dihydroxy-12,17;19,18-diolide on the basis of spectroscopic data analysis. Among all tested compounds, 2 showed a significant concentration-dependent antiaggregating activity when ADP (3 mu M) was used as agonist on rat platelets. Conversely, 1 increased ADP-induced plateletaggregation.
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