advanced glycation end-products (AGE) are linked to aging and correlated diseases. In this study we analysed both the cytotoxic and the oxidative/glycoxidative effects of 48 h exposure to subtoxic and subsequent toxic doses of AGE (ribose-glycated serum) in J774A.1 murine macrophage cells. the analysed end points (cytoxicity index, TBARs production pentosidine levels, GSH/GSSG, HsP70 suggest an adaptive response of macrophages to subtoxic doses of AGE
Antioxidant status in J7774A.1 macrophage cell line during chronic exposure to glycated serum
BASSI, ANNA MARIA;LEDDA, SABINA;PENCO, SUSANNA;ODETTI, PATRIZIO;COTTALASSO, DAMIANO
2005-01-01
Abstract
advanced glycation end-products (AGE) are linked to aging and correlated diseases. In this study we analysed both the cytotoxic and the oxidative/glycoxidative effects of 48 h exposure to subtoxic and subsequent toxic doses of AGE (ribose-glycated serum) in J774A.1 murine macrophage cells. the analysed end points (cytoxicity index, TBARs production pentosidine levels, GSH/GSSG, HsP70 suggest an adaptive response of macrophages to subtoxic doses of AGE
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