CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishAging is commonly associated with immune deficiency and dysregulation. The aging of the immune system involves a progressive reduction in naı¨ve T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. We have investigated frequency, phenotype, and function of CD3CD8CD28– CD25 T cells in healthy volunteers over a wide age range. We demonstrate that the frequency of CD3CD8CD28–CD25 T cells in healthy volunteers increases with age. Peripheral CD3CD8 CD28–CD25 T cells share phenotypic and functional features with CD3CD4CD25 regulatory T cells (Tregs): In particular, they strongly express CTLA-4 and forkhead box P3. We observed that in vitro, functional titration assays of CD3CD8 CD28–CD25 T cells show equivalent regulatory function in young and elderly donors, with suppression of proliferation and cytokine production in response to polyclonal T cell stimulation. Finally, CD3CD8CD28–CD25 T cells seem to specifically express the CD122 receptor. Altogether, these observations demonstrate an increase in peripheral blood CD8 Tregs associated with aging. J. Leukoc. Biol. 84: 000–000; 2008.
The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age. / SIMONE R; ZICCA A; D. SAVERINO. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - ELETTRONICO. - 84(2008), pp. 1454-1461.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age. |
| Autori: | |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Citazione: | The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age. / SIMONE R; ZICCA A; D. SAVERINO. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - ELETTRONICO. - 84(2008), pp. 1454-1461. |
| Abstract: | Aging is commonly associated with immune deficiency and dysregulation. The aging of the immune system involves a progressive reduction in naı¨ve T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. We have investigated frequency, phenotype, and function of CD3CD8CD28– CD25 T cells in healthy volunteers over a wide age range. We demonstrate that the frequency of CD3CD8CD28–CD25 T cells in healthy volunteers increases with age. Peripheral CD3CD8 CD28–CD25 T cells share phenotypic and functional features with CD3CD4CD25 regulatory T cells (Tregs): In particular, they strongly express CTLA-4 and forkhead box P3. We observed that in vitro, functional titration assays of CD3CD8 CD28–CD25 T cells show equivalent regulatory function in young and elderly donors, with suppression of proliferation and cytokine production in response to polyclonal T cell stimulation. Finally, CD3CD8CD28–CD25 T cells seem to specifically express the CD122 receptor. Altogether, these observations demonstrate an increase in peripheral blood CD8 Tregs associated with aging. J. Leukoc. Biol. 84: 000–000; 2008. |
| Handle: | http://hdl.handle.net/11567/226722 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
File in questo prodotto:
http://hdl.handle.net/11567/226722
Copyright © 2021