Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
DECAY OF HIV-1 2LTR DNA IN INFECTED INDIVIDUALS AFTER THREE TO EIGHT YEARS OF SUSTAINED CONTROL OF VIREMIA.
MURDACA, GIUSEPPE;PUPPO, FRANCESCO;INDIVERI, FRANCESCO;VARNIER, OLIVIERO
2005-01-01
Abstract
Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
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