The effect of coumermycin A, activity on the infection and replication of murine type C retroviruses was studied in vitro. The infectivity of five prototype ecotropic retroviruses was reduced by 50 to 94%, with viral titres decreased up to even-fold. These values were substantiated by progeny production studies. Similar results were obtained with five strains of xenotropic retroviruses. Delayed inhibition of growth kinetics in mouse SC-1 cells was observed with 7-5 and 10mg/l of coumermycin A This effect was markedly reduced after three cycles of freezing and thawing of the drug. Changes in the absorption spectra of coumermycin A, were observed after eight cycles of freezing and thawing.
Antiviral activity of Coumermycin: identification of resistant and sensitive retrovirus strains.
VARNIER, OLIVIERO;
1985-01-01
Abstract
The effect of coumermycin A, activity on the infection and replication of murine type C retroviruses was studied in vitro. The infectivity of five prototype ecotropic retroviruses was reduced by 50 to 94%, with viral titres decreased up to even-fold. These values were substantiated by progeny production studies. Similar results were obtained with five strains of xenotropic retroviruses. Delayed inhibition of growth kinetics in mouse SC-1 cells was observed with 7-5 and 10mg/l of coumermycin A This effect was markedly reduced after three cycles of freezing and thawing of the drug. Changes in the absorption spectra of coumermycin A, were observed after eight cycles of freezing and thawing.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
