Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in a severe pneumonia associated with elevation of blood inflammatory parameters, reminiscent of cytokine storm syndrome. Steroidal anti-inflammatory therapies have shown efficacy in reducing mortality in critically ill patients; however, the mechanisms by which SARS-CoV-2 triggers such an extensive inflammation remain unexplained.
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment
Bertoni, Arinna;Penco, Federica;Mollica, Hilaria;Del Zotto, Genny;Amaro, Adriana;Signa, Sara;Bustaffa, Marta;Caorsi, Roberta;Palmeri, Serena;Contini, Paola;De Palma, Raffaele;Pfeffer, Ulrich;Rubartelli, Anna;Gattorno, Marco;Volpi, Stefano
2022-01-01
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in a severe pneumonia associated with elevation of blood inflammatory parameters, reminiscent of cytokine storm syndrome. Steroidal anti-inflammatory therapies have shown efficacy in reducing mortality in critically ill patients; however, the mechanisms by which SARS-CoV-2 triggers such an extensive inflammation remain unexplained.
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