One of the possible risks associated with the implant of iris-fixated phakic intraocular lenses (pIOL) is loss of corneal endothelial cells. We hypothesize that this might be due to alterations in corneal metabolism secondary to the lens implanta- tion. To verify the feasibility of this assumption, we propose a mathematical model of the transport and diffusion of metabolic species in the anterior chamber and the cornea, coupled to a model of aqueous flow. Results are obtained both with and without the pIOL in the case of closed eyelids. The results suggest that glucose avail- ability may be significantly reduced at the corneal endothelium. However, it must still be verified whether this finding has clinical relevance.
Effect of an iris-fixated intraocular lens on corneal metabolism: a numerical study
Davvalo Khongar, Peyman;Pralits, Jan O.;Repetto, Rodolfo
2018-01-01
Abstract
One of the possible risks associated with the implant of iris-fixated phakic intraocular lenses (pIOL) is loss of corneal endothelial cells. We hypothesize that this might be due to alterations in corneal metabolism secondary to the lens implanta- tion. To verify the feasibility of this assumption, we propose a mathematical model of the transport and diffusion of metabolic species in the anterior chamber and the cornea, coupled to a model of aqueous flow. Results are obtained both with and without the pIOL in the case of closed eyelids. The results suggest that glucose avail- ability may be significantly reduced at the corneal endothelium. However, it must still be verified whether this finding has clinical relevance.
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