CKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF-κB mediate the response.
Mechanisms Regulating Muscle Protein Synthesis in Chronic Kidney Disease
Garibotto, Giacomo;
2020-01-01
Abstract
CKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF-κB mediate the response.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
garibotto 2.pdf
accesso aperto
Tipologia:
Documento in versione editoriale
Dimensione
910.58 kB
Formato
Adobe PDF
|
910.58 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
