IRIS
TONELLI, MICHELE
 Distribuzione geografica
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Continente #
EU - Europa 5.775
Totale 5.775
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Nazione #
IT - Italia 5.775
Totale 5.775
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Città #
Genova 3.813
Rapallo 684
Genoa 661
Vado Ligure 607
Bordighera 10
Totale 5.775
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Nome #
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents 192
Clofazimine analogs with antileishmanial and antiplasmodial activity 182
Antiviral activity of benzimidazole derivatives. II Antiviral activity of 2-phenylbenzimidazole derivatives. 165
Quinolizidinyl-benzimidazoles as platelet-antiaggregating agents 152
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 148
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives 148
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5 139
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 139
Acridine derivatives as anti-BVDV agents 137
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 134
Benzimidazole derivatives endowed with potent antileishmanial activity 134
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 129
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 128
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 124
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 120
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 118
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation 117
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines 116
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation 115
Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV) 112
Antimicrobial and cytotoxic arylazoenamines. Part III: Antiviral activity of selected classes of arylazoenamines 112
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 112
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 112
Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles. 108
New arylsparteine derivatives as positive inotropic drugs 106
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase 101
3-(4-Chlorophenyldiazenyl)-1-methyl-1,4,5,6-tetrahydropyridine, 101
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 101
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 99
9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp) 98
Antitubercular and antiprotozoal activities of quinolizidinyl/pyrrolizidinylalkyliminophenazines 91
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 91
Chapter 1. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HIV Infections 86
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 86
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 83
Synthesis and antiplasmodial activity of novel chloroquine analogues with bulky basic side chains 80
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 78
Look Back in Anger. Toxicity vs. Activity for Acridine Derivatives as HCV RNA Dependent RNA-polymerase Inhibitors 73
Quinolizidinyl derivatives of bi- and tricyclic systems as AChE/BchE and beta-amyloid aggregation inhibitors, 71
Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease 71
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 69
Chapter 2. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HCV and RSV Infections. 66
null 66
Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-([Formula: see text]-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines. 63
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 62
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 60
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 60
Journey on naphthoquinone and anthraquinone derivatives: New insights in alzheimer’s disease 57
Targeting species-specific TAAR1 ligands: to date perspective of the rational drug design process 52
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 48
Host DHFR-directed cycloguanil analogues endowed with promising activity against influenza virus and respiratory syncytial virus 47
New insights into the structure of the Trace Amine-Associated Receptor 2 (TAAR2): homology modeling studies exploring the binding mode of 3-iodothyronamine 43
Anti-α-glucosidase and antiglycation activities of α-mangostin and new xanthenone derivatives: Enzymatic kinetics and mechanistic insights through in vitro studies 43
Quinolizidine-derived lucanthone and amitriptyline analogues endowed with potent antileishmanial activity 41
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 41
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of trypanosoma brucei pteridine reductase and dihydrofolate reductase 38
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present) 37
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis 36
Quinone-based derivatives: a new class of multi-target agents against Alzheimer’s disease 36
null 35
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 34
New naphtho- and anthraquinone derivatives as Cholinesterase inhibitors for the treatment of Alzheimer's disease 34
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 31
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 31
Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies 31
Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery−Genetics Alliance Perspective 23
The breakthrough of TAAR1 agonists for the treatment of neuropsychiatric disorders: One step away 18
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 17
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo 16
Exploring the selectivity profile of sigma receptor ligands by molecular docking and pharmacophore analyses. 16
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 14
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents 11
Further quinolizidine derivatives as antiarrhythmic agents-3 10
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 9
Totale 6.010
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Categoria #
all - tutte 21.320
article - articoli 19.774
book - libri 0
conference - conferenze 1.111
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 435
Totale 42.640
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020851 0 0 0 0 0 0 207 115 128 220 144 37
2020/2021571 38 26 56 32 33 53 28 51 52 85 77 40
2021/2022824 49 33 94 70 22 45 47 175 59 59 57 114
2022/2023804 67 45 22 78 144 146 3 65 121 5 92 16
2023/2024547 24 67 38 73 37 112 33 32 18 7 49 57
2024/2025649 37 101 41 75 239 156 0 0 0 0 0 0
Totale 6.010