IRIS
VILLA, VALENTINA
 Distribuzione geografica
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Continente #
EU - Europa 4.890
Totale 4.890
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Nazione #
IT - Italia 4.890
Totale 4.890
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Città #
Genova 3.952
Rapallo 554
Genoa 365
Bordighera 19
Totale 4.890
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Nome #
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 152
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 149
Amyloid precursor protein modulates ERK1/2 signaling 148
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 148
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 145
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 144
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 139
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 139
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 135
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 127
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 120
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 119
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 119
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 118
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 116
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 115
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 114
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 113
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 113
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 112
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 111
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 111
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 111
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 110
Role of prion protein aggregation in neurotoxicity 109
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 100
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 100
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 100
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 93
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 92
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 91
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 90
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 90
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 86
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 85
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 83
Psychological treatments and psychotherapies in the neurorehabilitation of pain: Evidences and recommendations from the italian consensus conference on pain in neurorehabilitation 81
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 73
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 72
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 67
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 66
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 64
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 64
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 63
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 62
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 60
Somatostatin receptor expression in patients with stromal tumors of the gastrointestinal tract 51
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 51
Somatostatin receptor expression in stromal tumors of the gastrointestinal 43
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 37
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 4
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 2
Totale 5.007
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Categoria #
all - tutte 13.088
article - articoli 12.373
book - libri 0
conference - conferenze 566
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 149
Totale 26.176
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019210 0 0 0 0 0 0 0 0 0 0 113 97
2019/20201.326 47 31 51 72 129 157 208 97 110 216 165 43
2020/2021372 30 30 29 26 41 30 31 45 24 38 22 26
2021/2022672 16 75 35 68 20 52 61 149 20 54 32 90
2022/2023648 48 43 5 64 110 116 1 54 94 5 101 7
2023/2024292 22 33 7 49 22 87 28 21 17 6 0 0
Totale 5.007