IRIS
BRUZZONE, SANTINA
 Distribuzione geografica
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Continente #
EU - Europa 19.225
Totale 19.225
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Nazione #
IT - Italia 19.225
Totale 19.225
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Città #
Genova 14.772
Rapallo 2.291
Genoa 2.098
Bordighera 64
Totale 19.225
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Nome #
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP-ribose as second messenger. 177
Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin. 176
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 173
APO866 increases antitumor activity of cyclosporin - A by inducing mitochondrial and endoplasmic reticulum stress in leukemia cells 165
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 163
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents 163
Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair. 161
G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. 158
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells 153
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics 152
Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats 148
APO866 activity in hematologic malignancies: a preclinical in vitro study. 145
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose 144
Binding of abscisic acid to human LANCL2 143
G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2 139
Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice 139
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. 139
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model 138
Discovery of novel and selective SIRT6 inhibitors. 137
Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors As Therapeutics: Rationales, Controversies, Clinical Experience. 137
Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. 136
ABA says NO to UV-B: a universal response? 132
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody 132
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects 132
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. 132
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes 131
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. 131
Subcellular and intercellular traffic of NAD+, NAD+ precursors and NAD+-derived signalmetabolites and second messengers: Old and new topological paradoxes 130
Abscisic Acid: A Novel Nutraceutical for Glycemic Control 130
Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE 130
The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A 129
Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling. 129
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR. 129
Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro. 126
Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction. 126
Paracrine roles of NAD+ and Cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts 125
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. 124
Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells 124
Autocrine and paracrine calcium signalling by the CD38/NAD+/cyclic ADP-ribose system 123
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation 123
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. 123
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy 123
Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells 122
ABA- and cADPR-mediated effects on respiration and filtration downstream of the temperature-signaling cascade in sponges 120
Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis 119
Abscisic acid and cyclic ADP-ribose are first and second messanger in inflammatory cells, hematopoietic progenitors and pancreatic beta-cells 117
Mesenchymal stem cells shape microglia effector functions through the release of CX3CL1 117
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells 116
A self restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts 115
Synthetic analogues of abscisic acid with anti-inflammatory and insulin release stimulation effects on human cells 114
Fluridone as a new anti-inflammatory drug 114
Nicotinamide Phosphoribosyltransferase As A Target In Inflammation-Related Disorders. 114
Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors 114
Abscisic acid and cyclic ADP-ribose are first and second messengers in inflammatory cells and hemopoietic progenitors 113
Equilibrative and concentrative nucleoside transporters mediate the influx of Cyclic ADP-ribose into 3T3 murine fibroblasts. 113
Ectocellular CD38-catalyzed synthesis and intracellular Ca(2+)-mobilizing activity of cyclic ADP-ribose. 113
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line 111
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes 110
Selectivity hot-spots of sirtuin catalytic cores 109
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 108
Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation 108
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism 107
Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules 107
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes. 107
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose. 106
Functional characterization of a synthetic abscisic acid analog with anti-inflammatory activity on human granulocytes and monocytes 106
Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. 105
Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells. 105
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose 104
Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration 104
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes 104
Toward a medicine-oriented use of the human hormone/nutritional supplement Abscisic Acid 104
LANCL2 is necessary for Abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells 104
Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine 104
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. 103
Rejuvenating sirtuins: the rise of a new family of cancer drug targets 103
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes. 102
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 102
LANCL2 is the abscisic acid receptor in in human granulocytes and in rat insulinoma cells 100
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases 99
Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells 99
NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes. 99
The danger signal extracellular ATP is involved in the immunomediated damage of α-sarcoglycan deficient muscular dystrophy 99
Novel adenylic dinucleotides with anti-tumor activity and method of preparing thereof. 98
The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms 98
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts 97
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR 97
Abscisic acid produced by human monocytes stimulates monocyte and vascular smooth muscle cell responses involved in the development of the atherosclerotic lesion 97
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration 97
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors 96
CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose. 96
Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway. 95
TOPOLOGY OF CD38 94
The temperature-signaling cascade in sponges involves a heat-gated cation channel, abscisic acid, and cyclic ADP-ribose 94
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells. 93
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy 93
Catastrophic NAD+ Depletion through Nampt Inhibition in Activated T Lymphocytes Reduces Demyelination and Disability in EAE. 92
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells. 92
Abscisic acid is an endogenous stimulator of insulin release from human release from human pancreatic islets with cyclic ADP-ribose as second messenger. 91
LANCL2 is the abscisic acid receptor in human granulocytes and in rat insulinoma cells. 91
Totale 11.921
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Categoria #
all - tutte 53.885
article - articoli 43.841
book - libri 0
conference - conferenze 8.252
curatela - curatele 0
other - altro 0
patent - brevetti 1.591
selected - selezionate 0
volume - volumi 201
Totale 107.770
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019365 0 0 0 0 0 0 0 0 0 0 0 365
2019/20205.083 214 120 216 279 471 561 802 316 408 900 616 180
2020/20211.399 75 127 123 115 124 122 45 131 131 197 110 99
2021/20222.648 72 221 246 280 86 146 178 584 118 248 94 375
2022/20232.769 253 217 43 293 489 404 15 210 443 12 357 33
2023/20241.738 84 195 72 272 187 396 124 119 99 58 130 2
Totale 19.612