IRIS
BRUZZONE, SANTINA
 Distribuzione geografica
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Continente #
EU - Europa 21.818
Totale 21.818
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Nazione #
IT - Italia 21.818
Totale 21.818
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Città #
Genova 14.772
Genoa 2.668
Rapallo 2.291
Vado Ligure 2.024
Bordighera 63
Totale 21.818
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Nome #
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP-ribose as second messenger. 186
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 185
Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin. 185
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 181
APO866 increases antitumor activity of cyclosporin - A by inducing mitochondrial and endoplasmic reticulum stress in leukemia cells 178
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents 174
G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. 172
Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair. 170
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics 165
APO866 activity in hematologic malignancies: a preclinical in vitro study. 161
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells 161
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose 157
Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats 157
Binding of abscisic acid to human LANCL2 153
Discovery of novel and selective SIRT6 inhibitors. 150
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. 150
G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2 149
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model 148
The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A 147
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. 147
Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE 147
Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice 146
Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors As Therapeutics: Rationales, Controversies, Clinical Experience. 146
Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro. 143
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects 143
Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. 143
ABA says NO to UV-B: a universal response? 142
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes 141
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody 139
Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells 139
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. 138
Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction. 138
Subcellular and intercellular traffic of NAD+, NAD+ precursors and NAD+-derived signalmetabolites and second messengers: Old and new topological paradoxes 137
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. 136
Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling. 135
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. 135
Abscisic Acid: A Novel Nutraceutical for Glycemic Control 134
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR. 134
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy 133
Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis 132
Paracrine roles of NAD+ and Cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts 131
Mesenchymal stem cells shape microglia effector functions through the release of CX3CL1 131
ABA- and cADPR-mediated effects on respiration and filtration downstream of the temperature-signaling cascade in sponges 130
Autocrine and paracrine calcium signalling by the CD38/NAD+/cyclic ADP-ribose system 129
Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells 129
Abscisic acid and cyclic ADP-ribose are first and second messanger in inflammatory cells, hematopoietic progenitors and pancreatic beta-cells 129
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells 128
Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors 128
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation 127
A self restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts 126
Abscisic acid and cyclic ADP-ribose are first and second messengers in inflammatory cells and hemopoietic progenitors 123
Synthetic analogues of abscisic acid with anti-inflammatory and insulin release stimulation effects on human cells 123
Selectivity hot-spots of sirtuin catalytic cores 122
Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation 122
Fluridone as a new anti-inflammatory drug 121
Nicotinamide Phosphoribosyltransferase As A Target In Inflammation-Related Disorders. 121
Equilibrative and concentrative nucleoside transporters mediate the influx of Cyclic ADP-ribose into 3T3 murine fibroblasts. 120
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 120
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes 120
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose 119
Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration 119
Ectocellular CD38-catalyzed synthesis and intracellular Ca(2+)-mobilizing activity of cyclic ADP-ribose. 119
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line 118
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes. 118
Functional characterization of a synthetic abscisic acid analog with anti-inflammatory activity on human granulocytes and monocytes 117
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 117
Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules 116
LANCL2 is necessary for Abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells 114
Rejuvenating sirtuins: the rise of a new family of cancer drug targets 113
Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells. 112
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism 112
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. 112
Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. 111
LANCL2 is the abscisic acid receptor in in human granulocytes and in rat insulinoma cells 111
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose. 111
Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine 111
Toward a medicine-oriented use of the human hormone/nutritional supplement Abscisic Acid 110
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration 110
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes. 109
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes 109
NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes. 109
The danger signal extracellular ATP is involved in the immunomediated damage of α-sarcoglycan deficient muscular dystrophy 109
Novel adenylic dinucleotides with anti-tumor activity and method of preparing thereof. 107
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts 107
Abscisic acid produced by human monocytes stimulates monocyte and vascular smooth muscle cell responses involved in the development of the atherosclerotic lesion 107
Abscisic acid and cyclic ADP-ribose increase intracellular Ca2+ and stimulate proliferation of human mesenchymal stem cells. 105
The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms 105
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy 105
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells. 104
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors 104
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases 103
Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells 103
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes 103
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR 102
P2X7 antagonists improve “in vitro” myelination in organotypic dorsal root ganglia (DRG) cultures from a rat model of CMT1A neuropathy 102
CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose. 102
Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway. 101
LANCL2 is the abscisic acid receptor in human granulocytes and in rat insulinoma cells. 100
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells. 100
TOPOLOGY OF CD38 99
Totale 12.902
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Categoria #
all - tutte 70.176
article - articoli 56.208
book - libri 0
conference - conferenze 11.697
curatela - curatele 0
other - altro 0
patent - brevetti 2.026
selected - selezionate 0
volume - volumi 245
Totale 140.352
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.222 0 0 0 0 0 0 802 316 408 900 616 180
2020/20211.399 75 127 123 115 124 122 45 131 131 197 110 99
2021/20222.648 72 221 246 280 86 146 178 584 118 248 94 375
2022/20232.769 253 217 43 293 489 404 15 210 443 12 357 33
2023/20241.987 84 195 72 272 186 396 124 118 99 58 128 255
2024/20252.376 303 340 227 427 576 459 44 0 0 0 0 0
Totale 22.237